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In the present study, we examined putative disruptions in communication within a well\u2010known cortico\u2010limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present investigation employed a within\u2010 and between\u2010subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>; N<jats:italic>\u00a0=\u00a0<\/jats:italic>24) and a healthy non\u2010psychiatric control group (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>; N<jats:italic>\u00a0=\u00a0<\/jats:italic>25) during functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>). Participants in the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group were remitted at the time of testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Functional connectivity analyses revealed increased connectivity between the ventral striatum (<jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>) seed region and orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>) as well as the amygdala during processing of reward receipt in the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group. After omission of expected rewards, the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group showed decreased functional connectivity between the VS and a medial frontopolar cortex (<jats:styled-content style=\"fixed-case\">mFPC<\/jats:styled-content>) region associated with consideration of behavioral alternatives. Follow\u2010up analyses within the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group showed that increased <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> connectivity after reward receipt, and decreased <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mFPC<\/jats:styled-content> connected after reward omission, were associated with higher levels of subthreshold mania symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results point toward potential mechanisms implicated in elevated reward sensitivity in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Enhanced <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> connectivity after reward receipt may be involved in elevated valuation of rewards whereas blunted <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mFPC<\/jats:styled-content> connectivity after reward omission may reflect a failure to consider behavioral alternatives to reward pursuit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12560","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T14:42:37Z","timestamp":1507732957000},"page":"661-675","source":"Crossref","is-referenced-by-count":34,"title":["Disrupted cortico\u2010limbic connectivity during reward processing in remitted bipolar I disorder"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-5913","authenticated-orcid":false,"given":"Sunny 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