{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:46:38Z","timestamp":1792010798148,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western Norway Health Authority and the participating hospitals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long\u2010term neurocognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter randomized controlled trial, in\u2010patients with treatment\u2010resistant bipolar depression were randomized to either algorithm\u2010based pharmacologic treatment or right unilateral electroconvulsive therapy. After the 6\u2010week treatment period, all of the patients received maintenance pharmacotherapy as recommended by their clinician guided by a relevant treatment algorithm. Patients were assessed at baseline and at 6\u00a0months. Neurocognitive functions were assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia (<jats:styled-content style=\"fixed-case\">MATRICS<\/jats:styled-content>) Consensus Cognitive Battery, and autobiographical memory consistency was assessed using the Autobiographical Memory Interview\u2010Short Form.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients entered the trial, of whom 51 and 26 completed neurocognitive assessments at baseline and 6\u00a0months, respectively. The<jats:styled-content style=\"fixed-case\">MATRICS<\/jats:styled-content>Consensus Cognitive Battery composite score improved by 4.1 points in both groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.042) from baseline to 6\u00a0months (from 40.8 to 44.9 and from 41.9 to 46.0 in the algorithm\u2010based pharmacologic treatment and electroconvulsive therapy groups, respectively). The Autobiographical Memory Interview\u2010Short Form consistency scores were reduced in both groups (72.3% vs 64.3% in the algorithm\u2010based pharmacologic treatment and electroconvulsive therapy groups, respectively;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.085).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study did not find that right unilateral electroconvulsive therapy caused long\u2010term impairment in neurocognitive functions compared to algorithm\u2010based pharmacologic treatment in bipolar depression as measured using standard neuropsychological tests, but due to the low number of patients in the study the results should be interpreted with caution.<\/jats:p><jats:p><jats:bold>Trial registration:<\/jats:bold>ClinicalTrials.gov: NCT00664976<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12594","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T15:09:29Z","timestamp":1514041769000},"page":"531-538","source":"Crossref","is-referenced-by-count":15,"title":["Right unilateral electroconvulsive therapy does not cause more cognitive impairment than pharmacologic treatment in treatment\u2010resistant bipolar depression: A 6\u2010month randomized controlled trial follow\u2010up study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-088X","authenticated-orcid":false,"given":"Jeanette","family":"Bjoerke\u2010Bertheussen","sequence":"first","affiliation":[{"name":"Department of Psychiatry Helse Stavanger Stavanger Universitetssjukehus Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Schoeyen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Helse Stavanger Stavanger Universitetssjukehus Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole A","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Oslo Universitetssykehus Ulleval Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik F","family":"Malt","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry and Psychosomatic Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketil J","family":"Oedegaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Morken","sequence":"additional","affiliation":[{"name":"Sankt Olavs Hospital Universitetssykehuset i Trondheim Trondheim 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