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The review also sought to establish the utility of clinical stage modelling as a framework for identifying precursor disorders to later onset of bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">OPBD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was performed using <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Psych<jats:styled-content style=\"fixed-case\">INFO<\/jats:styled-content> and Medline. Reference lists of included studies and previous reviews were also searched. Studies were included if they reported diagnostic outcomes for child, adolescent and young adult offspring of parents diagnosed with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six studies were identified representing 21 individual cohorts. The review identified that <jats:styled-content style=\"fixed-case\">OBPD<\/jats:styled-content> present as a high\u2010risk group for a range of mood and non\u2010mood disorders in childhood, adolescence and young adulthood. The trajectory of risk was from non\u2010mood disorders in childhood via non\u2010bipolar mood disorders in early adolescence towards mania\/hypomania in late adolescence and early adulthood. From a clinical staging perspective, childhood anxiety disorders were associated with later onset of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Recurrent substance use disorder was identified as a risk in <jats:styled-content style=\"fixed-case\">OPBD<\/jats:styled-content> during late adolescence and early adulthood. Quality ratings indicated that studies were methodologically robust.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our review provides evidence for a developmental psychopathology trajectory of precursor risks to <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">OPBD<\/jats:styled-content>. There is support for clinical stage modelling as a conceptual framework for understanding developmental risk in <jats:styled-content style=\"fixed-case\">OPBD<\/jats:styled-content> and as a tool for developing early and individualized intervention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12604","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T09:12:51Z","timestamp":1518685971000},"page":"313-333","source":"Crossref","is-referenced-by-count":26,"title":["Clinical staging model in offspring of parents with bipolar disorder: a systematic review"],"prefix":"10.1111","volume":"20","author":[{"given":"Aigli","family":"Raouna","sequence":"first","affiliation":[{"name":"Department of Clinical and Health Psychology University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemre Su","family":"Osam","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"MacBeth","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae). 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