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Patients were medication free at assessment and had no or limited exposure to mood\u2010stabilizer or antipsychotic medications prior to the current admission. Associations among cardiometabolic parameters and Clinical Global Impression\u2014Severity scale (<jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content>\u2010S), manic (<jats:styled-content style=\"fixed-case\">Young Mania Rating Scale [YMRS]<\/jats:styled-content>), and depressive (Hamilton Depression Rating Scale <jats:styled-content style=\"fixed-case\">[HDRS]<\/jats:styled-content>) symptom ratings were evaluated within the bipolar group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following adjustment for demographic variables (i.e., age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> vs 87.0\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>;<jats:italic> P<\/jats:italic>&lt;.01). There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose. Nineteen percent of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome (<jats:italic>P<\/jats:italic>=.23). The omega\u20103 index was lower in the bipolar group (3.4% vs 3.9%; <jats:italic>P<\/jats:italic>&lt;.01). Within the bipolar group, no associations were found between the cardiometabolic parameters and <jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content>\u2010S, <jats:styled-content style=\"fixed-case\">YMRS,<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HDRS<\/jats:styled-content> symptom ratings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recent\u2010onset medication\u2010free bipolar disorder is associated with higher triglyceride levels. These findings are suggestive of early metabolic dysregulation prior to long\u2010term psychotropic medication exposure. Lower omega\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12633","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:11:00Z","timestamp":1519625460000},"page":"658-665","source":"Crossref","is-referenced-by-count":15,"title":["Cardiometabolic risks and omega\u20103 index in recent\u2010onset bipolar I disorder"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-3507","authenticated-orcid":false,"given":"Lawson R","family":"Wulsin","sequence":"first","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb M","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-8114","authenticated-orcid":false,"given":"Robert K","family":"McNamara","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Strakowski","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry 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