{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:43:40Z","timestamp":1791859420606,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007201","name":"Utah Science Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007201","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Structural abnormalities in cortical and subcortical regions, including the orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>), are altered during brain development in adolescents with bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>), which may increase risk for suicide. Few studies have examined the neural substrates of suicidal behavior in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> youth. The aim of the present study was to investigate the relationship between suicide behavior and the <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> in youth with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven participants with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and 26 non\u2010psychiatric controls, ages 13\u201021\u00a0years, completed a diagnostic interview and mood rating scales. Lifetime symptoms of suicide ideation and behavior were examined using the Columbia Suicide Severity Rating Scale. Participants underwent magnetic resonance imaging on a 3T Siemens Verio scanner. Morphometric analysis of brain images was performed using FreeSurfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen participants with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> had a history of suicide attempt (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>). Bipolar youth with a history of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> showed reduced left lateral <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> volumes compared to controls, but there was no difference between <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> attempters and non\u2010attempters. Controls and <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> non\u2010attempters had significantly greater <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> cortical thickness than <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> attempters. Additionally, there was a significant negative correlation between <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> volumes and suicide lethality, demonstrating that as suicide lethality increased, <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> volume in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> youth was reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> is involved in decision\u2010making, impulsivity, and reward circuitry which have shown to be impaired in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Reduced <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> volume and its association with lethality of suicide suggest that suicide behavior in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> may be related to the emerging neuroanatomical substrates of the disorder, particularly abnormalities of the <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12729","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T16:29:51Z","timestamp":1543076991000},"page":"321-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Reduced lateral orbitofrontal cortex volume and suicide behavior in youth with bipolar disorder"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-9683","authenticated-orcid":false,"given":"Rebekah 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