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Only a small number of longitudinal studies of manic patients, in particular, have been carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six bipolar patients underwent fMRI during performance of the n\u2010back working memory task when manic and again after recovery. Twenty\u2010six matched healthy controls were also scanned on two occasions. Task\u2010related activations and de\u2010activations were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When manic, the patients showed clusters of significantly reduced activation in the left dorsolateral prefrontal cortex (DLPFC)\/precentral cortex and the parietal cortex\/superior precuneus bilaterally. They also showed failure of de\u2010activation in the ventromedial frontal cortex (vmPFC). After recovery, activation in the left DLPFC\/precentral cortex and in the bilateral parietal cortex\/superior precuneus clusters increased significantly. However, failure of de\u2010activation remained present in the vmPFC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recovery from mania is associated with normalization of DLPFC and parietal hypoactivation, but not with vmPFC failure of de\u2010activation, which accordingly appears to represent a trait abnormality in the disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12767","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T10:39:38Z","timestamp":1552041578000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Longitudinal brain functional changes between mania and euthymia in bipolar disorder"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-6929","authenticated-orcid":false,"given":"Silvia","family":"Alonso\u2010Lana","sequence":"first","affiliation":[{"name":"FIDMAG Germanes 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