{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:41:58Z","timestamp":1793148118744,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["6110-00096B"],"award-info":[{"award-number":["6110-00096B"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation\u2010wide population\u2010based registers to investigate whether continued use of non\u2010aspirin non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), low\u2010dose aspirin, high\u2010dose aspirin, statins, allopurinol, and angiotensin agents decrease the rate of incident mania\/bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nation\u2010wide population\u2010based longitudinal study using Poisson regression analyses including all persons in Denmark who purchased the exposure medication of interest and a random sample of 30% of the Danish population. The follow\u2010up period comprised a 10\u00a0years period from 2005 to 2015. Two different outcome measures were included, (1) a diagnosis of mania\/bipolar disorder at a psychiatric hospital contact as inpatient or outpatient and (2) a combined measure of a diagnosis of mania\/bipolar disorder or initiation of lithium use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,605,365 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015, median age 57\u00a0years [quartiles: 43;69], and female proportion of 53.1%. Continued use of low\u2010dose aspirin, statins, and angiotensin agents were associated with decreased rates of incident mania\/bipolar disorder on both outcome measures. Continued uses of non\u2010aspirin NSAIDs as well as high\u2010dose aspirin were associated with an increased rate of incident bipolar disorder. There were no statistically significant associations for allopurinol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study supports the potential of agents acting on inflammation and the stress response system in bipolar disorder and illustrates that population\u2010based registers can be used to systematically identify drugs with repurposing potentials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12772","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T06:38:35Z","timestamp":1552631915000},"page":"410-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["New drug candidates for bipolar disorder\u2014A nation\u2010wide population\u2010based study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9377-9436","authenticated-orcid":false,"given":"Lars V.","family":"Kessing","sequence":"first","affiliation":[{"name":"Psychiatric Center Copenhagen, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene C.","family":"Rytgaard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Gerds","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"School of Medicine Deakin University Melbourne Australia"},{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Department of Psychiatry, Florey Institute for Neuroscience and Mental Health University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus T.","family":"Ekstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Organization WH.The global burden of disease.2008.http:\/\/www.who.int\/healthinfo\/global_burden_disease\/GBD_report_2004update_full.pdf. 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