{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:07:34Z","timestamp":1783127254580,"version":"3.54.6"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Substance use disorders (SUDs), including those for alcohol, stimulants, tobacco, opioids and cannabis, in patients with bipolar disorder are a major clinical and public health problem, and are present in the majority of these patients. Nonetheless, the development of effective pharmacological treatments for co\u2010occurring SUDs in bipolar illness have not been well\u2010developed and may be an important practical reason for the reduced effectiveness of these medications in community practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review of the literature (PubMed, Medline, Google Scholar), and identified N\u00a0=\u00a029 clinical studies, which evaluated both mental health and SUD outcomes in patients with co\u2010occurring bipolar disorders and SUDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings suggest the potential of valproate sodium and lamotrigine as preferred pharmacological agents for the treatment of co\u2010occurring psychiatric and substance use outcomes in these patients. However, many of the reviewed studies are of open\u2010label designs and of modest sample sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thus, given the gaps in our knowledge, recommendations for treatment of this common and important co\u2010morbidity are preliminary. Accordingly, the conduct of larger, randomized controlled trials for this co\u2010morbidity is clearly needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12794","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:28:56Z","timestamp":1557581336000},"page":"595-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pharmacotherapies for co\u2010occurring substance use and bipolar disorders: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-8793","authenticated-orcid":false,"given":"Alexandria S.","family":"Coles","sequence":"first","affiliation":[{"name":"Addictions Division Centre for Addiction and Mental Health Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sasiadek","sequence":"additional","affiliation":[{"name":"Addictions Division Centre for Addiction and Mental 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