{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:17:35Z","timestamp":1790281055958,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH078113"],"award-info":[{"award-number":["R01MH078113"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH080729"],"award-info":[{"award-number":["R01MH080729"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH096942"],"award-info":[{"award-number":["R01MH096942"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005615","name":"Beth Israel Deaconess Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate whether dynamic Arterial Spin Labeling (dASL), a novel quantitative technique robust to artifacts and noise that especially arise in inferior brain regions, could characterize neural substrates of BD pathology and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five subjects (19 BD patients, 26 controls) were imaged using a dASL sequence. Maps of average perfusion, perfusion fluctuation, and perfusion connectivity with anterior cingulate cortex (ACC) were derived. Patient symptoms were quantified along four symptom dimensions determined using factor analysis of the subjects from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (BSNIP) study. Maps of the perfusion measures were compared between BD patients and controls and correlated with the symptom dimensions in the BD patients only by voxel\u2010level and region\u2010level analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BD patients exhibited (i) significantly increased perfusion fluctuations in the left fusiform and inferior temporal regions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.020, voxel\u2010level corrected) and marginally increased perfusion fluctuations in the right temporal pole and inferior temporal regions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.063, cluster\u2010level corrected), (ii) significantly increased perfusion connectivity between ACC and the occipitoparietal cortex (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.050, cluster\u2010level corrected). In BD patients, positive symptoms were negatively associated with ACC perfusion connectivity to the right orbitofrontal and superior frontal regions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, cluster\u2010level corrected) and right orbitofrontal and inferior frontal regions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.023, cluster\u2010level corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The abnormal perfusion fluctuations and connectivity alterations may underlie the mood fluctuations and cognitive and emotional dysregulation that characterize BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12856","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T13:59:45Z","timestamp":1571579985000},"page":"401-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal perfusion fluctuation and perfusion connectivity in bipolar disorder measured 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas R.","family":"Bolo","sequence":"additional","affiliation":[{"name":"Psychiatry Beth Israel Deaconess Medical Center &amp; Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Tamminga","sequence":"additional","affiliation":[{"name":"Psychiatry University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Clementz","sequence":"additional","affiliation":[{"name":"Psychology and Neuroscience University of Georgia Athens GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[{"name":"Psychiatry Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Alsop","sequence":"additional","affiliation":[{"name":"Radiology Beth 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