{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:31:10Z","timestamp":1777624270986,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 172 outpatients, diagnosed with BD according to DSM\u2010IV\u2010TR criteria, and 150 healthy control (HC) participants. High\u2010resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with depressive PP (BD\u2010DP) and with uncertain PP (BD\u2010UP) but not with manic\/hypomanic PP (BD\u2010MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD\u2010DP presented with smaller bilateral presubiculum\/subiculum volumes than BD\u2010MP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12857","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T13:34:55Z","timestamp":1571578495000},"page":"490-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Predominant polarity and hippocampal subfield volumes in Bipolar disorders"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2485-6121","authenticated-orcid":false,"given":"Delfina","family":"Janiri","sequence":"first","affiliation":[{"name":"Department of Neurology and Psychiatry Sapienza University of Rome Rome Italy"},{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA"},{"name":"Lucio Bini Center Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Sapienza University of Rome Rome Italy"},{"name":"Lucio Bini Center Rome Italy"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Piras","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Ciullo","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-4249","authenticated-orcid":false,"given":"Gianfranco","family":"Spalletta","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA"},{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Sani","sequence":"additional","affiliation":[{"name":"Lucio Bini Center Rome Italy"},{"name":"NESMOS Department (Neurosciences, Mental Health, and Sensory Organs) Sapienza University of Rome School of Medicine and Psychology Sant\u2019Andrea Hospital Rome Italy"},{"name":"Tufts Medical Center Tufts University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61611-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-192104000-00057"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.01.032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.11.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01818.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160607101400"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.11.051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.03.016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.227"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12516"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.453"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7647-8_20"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.071"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"41","article-title":"A meta\u2010analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder","volume":"34","author":"Mckinnon MC","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.69"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_8_22_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition. 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