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We conducted a network analysis of mood symptoms in adolescents with or at risk for bipolar spectrum disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample consisted of 272 treatment\u2010seeking adolescents with or at high risk for bipolar disorder who had at least subsyndromal depressive or (hypo)manic symptoms. Based on symptom scores assessed via semi\u2010structured interviews, we constructed the network of depressive and manic symptoms and identified the most central symptoms and symptom communities within the network. We used bootstrapping analyses to determine the reliability of network parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptoms within the depressive and manic mood poles were more related to each other than to symptoms of the opposing mood pole. Four communities were identified, including a depressive symptom community and three manic symptom communities. Fatigue and depressed mood were the strongest individual symptoms within the overall network (ie the most highly correlated with other symptoms), followed by motor hyperactivity. Mood lability and irritability were found to be \u201cbridge\u201d symptoms that connected the two mood poles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptoms of activity\/energy (ie\u00a0fatigue and hyperactivity) and depressed mood are the most prominent mood symptoms among youth with bipolar spectrum disorders. Mood lability and irritability represent potential warning signs of emergent episodes of either polarity. Targeting these central and bridge symptoms would lead to more efficient assessments and therapeutic interventions for bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12870","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:59:11Z","timestamp":1573819151000},"page":"128-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Network analysis of mood symptoms in adolescents with or at high risk for bipolar disorder"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-120X","authenticated-orcid":false,"given":"Marc J.","family":"Weintraub","sequence":"first","affiliation":[{"name":"Jane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Schneck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Miklowitz","sequence":"additional","affiliation":[{"name":"Jane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles CA 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