{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:19Z","timestamp":1790377099603,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA: MH002778\u201018"],"award-info":[{"award-number":["ZIA: MH002778\u201018"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto\u2010limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n\u00a0=\u00a036 first\u2010degree relatives, REL) to youth with BD (n\u00a0=\u00a036) and healthy volunteers (n\u00a0=\u00a036, HV) using diffusion tensor imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)\/corticospinal tract (CST) and the body of the corpus callosum. WM microstructure of the anterior CC showed reduced age\u2010related in\u2010creases in BD compared to REL and HV. Further, individuals with BD and REL showed in\u2010creased difficulties in emotion regulation, which were associated with the microstructure of the anterior thalamic radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Alterations in the SCR\/CST and the body of the corpus callosum appear to represent a trait marker of BD, whereas changes in other WM tracts seem to be a disease state marker. Our findings also support the role of aberrant developmental trajectories of WM microstructure in the risk architecture of BD, although longitudinal studies are needed to confirm this association. Finally, our findings show the relevance of WM microstructure for difficulties in emotion regulation\u2014a core characteristic of BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12885","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T18:41:02Z","timestamp":1577558462000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["White matter microstructure in youth with and at risk for bipolar disorder"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-2194","authenticated-orcid":false,"given":"Julia O.","family":"Linke","sequence":"first","affiliation":[{"name":"Emotion and Development Branch National Institute of Mental Health National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Stavish","sequence":"additional","affiliation":[{"name":"Emotion and 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