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Although widely accepted, the neurobiological bases of the disorder in the euthymic phase remain elusive. This study aims at characterizing resting state functional activity of the BD euthymic phase in order to better understand the pathogenesis of the disease and build future neurobiological models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen euthymic BD patients (10 females; mean age 40.2; standard deviation 13.5; range 20\u201361) and 27 healthy controls (HC) (21 females; mean age 37; standard deviation 10.6; range 22\u201360) underwent a 3T functional MRI scan at rest. Resting state activity was extracted through independent component analysis (ICA) run with automatic dimensionality estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ICA identified 22 resting state networks (RSNs). Within\u2010network analysis revealed decreased connectivity in the visual, temporal, motor and cerebellar RSNs of BD patients vs HC. Between\u2010network analysis showed increased connectivity between motor area and the default mode network (DMN) partially overlapping with the fronto\u2010parietal network (FPN) in BD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within\u2010network analysis confirmed existing evidence of altered cerebellar, temporal, motor and visual networks in BD. Increased connectivity between the DMN and the motor area network suggests the presence of alterations of the fronto\u2010parietal regions, precuneus and cingulate cortex in the euthymic condition. These findings indicate that specific connectivity alterations might persist even in the euthymic state suggesting the importance of examining both within and between\u2010network connectivity to achieve a global understanding of the BD euthymic condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12900","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T16:59:20Z","timestamp":1585155560000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Resting state networks activity in euthymic bipolar disorder"],"prefix":"10.1111","volume":"22","author":[{"given":"Marcella","family":"Bellani","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences Section of Psychiatry University of Verona Verona 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