{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:44:49Z","timestamp":1788547489559,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The Korean Medication Algorithm Project for Bipolar Disorder (KMAP\u2010BP) is based on expert consensus and has been revised five times since 2002. This study evaluated the changes in treatment strategies advocated by the KMAP\u2010BP over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The five editions of the KMAP\u2010BP were reviewed, and the recommendations of the KMAP\u2010BP were compared with those of other bipolar disorder (BP) treatment guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most preferred option for the initial treatment of mania was a combination of a mood stabilizer (MS) and an atypical antipsychotic (AAP). Either MS or AAP monotherapy was also considered a first\u2010line strategy for mania, but not for all types of episodes, including mixed\/psychotic mania. In general, although lithium and valproic acid were commonly recommended, valproic acid has been increasingly preferred for all phases of BP. The most notable changes over time included the increasing preference for AAPs for all phases of BP, and lamotrigine for the depressive and maintenance phases. The use of antidepressants for BP has gradually decreased, but still represents a first\u2010line option for severe and psychotic depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In general, the recommended strategies of the KMAP\u2010BP were similar to those of other guidelines, but differed in terms of the emphasis on rapid effectiveness, which is often desirable in actual clinical situations. The major limitation of the KMAP\u2010BP is that it is a consensus\u2010based rather than an evidence\u2010based tool. Nevertheless, it may confer advantages in actual clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12902","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T03:30:18Z","timestamp":1584934218000},"page":"461-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Korean Medication Algorithm Project for Bipolar Disorder (KMAP\u2010BP): Changes in preferred treatment strategies and medications over 16 years and five editions"],"prefix":"10.1111","volume":"22","author":[{"given":"Duk\u2010In","family":"Jon","sequence":"first","affiliation":[{"name":"Department of Psychiatry Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sup","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Konkuk University Chungju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Goo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Inje University Haeundae Paik Hospital Inje University College of Medicine and Paik Institute for Clinical Research Busan Korea"},{"name":"Department of Health Science and Technology Graduate School of Inje University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hyun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine The Catholic University of Korea Seoul 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