{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:55:51Z","timestamp":1785545751462,"version":"3.56.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","award":["KOFC170016"],"award-info":[{"award-number":["KOFC170016"]}],"id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Lithium remains an important treatment for mood disorders but is associated with kidney disease. Nephrogenic diabetes insipidus (NDI) is associated with up to 3\u2010fold risk of incident chronic kidney disease among lithium users. There are limited randomized controlled trials (RCT) for treatments of lithium\u2010induced NDI, and existing therapies can be poorly tolerated. Therefore, novel treatments are needed for lithium\u2010induced NDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a 12\u2010week double\u2010blind pilot RCT to assess the feasibility and efficacy of 20\u00a0mg\/d atorvastatin vs placebo in the treatment of NDI in chronic lithium users. Patients, recruited between September 2017 and October 2018, were aged 18 to 85, currently on a stable dose of lithium, and determined to have NDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Urinary osmolality (UOsm) at 12\u00a0weeks adjusted for baseline was not statistically different between groups (+39.6\u00a0mOsm\/kg [95% CI, \u221235.3, 114.5] in atorvastatin compared to placebo groups). Secondary outcomes of fluid intake and aquaporin\u20102 excretions at 12\u00a0weeks adjusted for baseline were \u22120.13 L [95% CI, \u22120.54, 0.28] and 98.68 [95% CI, \u2212190.34, 387.70], respectively. A moderate effect size was observed for improvements in baseline UOsm by \u2265100\u00a0mOsm\/kg at 12\u00a0weeks in patients who received atorvastatin compared to placebo (38.45% (10\/26) vs 22.58% (7\/31); Cohen's d\u00a0=\u00a00.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among lithium users with NDI, atorvastatin 20\u00a0mg\/d did not significantly improve urinary osmolality compared to placebo over a 12\u2010week period. Larger confirmatory trials with longer follow\u2010up periods may help to further assess the effects of statins on NDI, especially within patients with more severe NDI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12973","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T12:49:37Z","timestamp":1593866977000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A double\u2010blind, randomized, placebo\u2010controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-995X","authenticated-orcid":false,"given":"Jocelyn","family":"Fotso Soh","sequence":"first","affiliation":[{"name":"Geri\u2010PARTy Research Group Jewish General Hospital Montreal QC Canada"},{"name":"Douglas Mental Health University Institute Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Trepiccione","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-7215","authenticated-orcid":false,"given":"Outi","family":"Linnaranta","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Torres\u2010Platas","sequence":"additional","affiliation":[{"name":"Geri\u2010PARTy Research Group Jewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane","family":"Renaud","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Lin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Mucsi","sequence":"additional","affiliation":[{"name":"Division of Nephrology University Health Network University of Toronto (UofT) Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"D\u2019Apolito","sequence":"additional","affiliation":[{"name":"Biogem S.c.a.r.l. 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