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Little is known about functional activation and connectivity in the brain of BD youths in response to frustration. This exploratory study compared BD youths and HV on attentional abilities, self\u2010reported affect, and functional activation and connectivity during a frustrating attention task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty BD (M<jats:sub>age<\/jats:sub>\u00a0=\u00a015.86) and 20 HV (M<jats:sub>age<\/jats:sub>\u00a0=\u00a015.55) youths completed an fMRI paradigm that differentiated neural responses during processing of frustrating feedback from neural responses during attention orienting following frustrating feedback. We examined group differences in (a) functional connectivity using amygdala, inferior frontal gyrus (IFG), and striatum as seeds and (b) whole\u2010brain and regions of interest (amygdala, IFG, striatum) activation. We explored task performance (accuracy, reaction time), self\u2010reported frustration and unhappiness, and correlations between these variables and irritability, depressive, and manic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bipolar disorder youths, relative to HV, exhibited positive IFG\u2010ventromedial prefrontal cortex (vmPFC) connectivity yet failed to show negative striatum\u2010insula connectivity during feedback processing. Irritability symptoms were positively associated with striatum\u2010insula connectivity during feedback processing. Moreover, BD vs HV youths showed positive IFG\u2010parahippocampal gyrus (PHG)\/periaqueductal gray (PAG) connectivity and negative amygdala\u2010cerebellum connectivity during attention orienting following frustration. BD was not associated with atypical activation patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive IFG\u2010vmPFC connectivity and striatum\u2010insula decoupling in BD during feedback processing may mediate heightened sensitivity to reward\u2010relevant stimuli. Elevated IFG\u2010PAG\/PHG connectivity in BD following frustration may suggest greater recruitment of attention network to regulate arousal and maintain goal\u2010directed behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12985","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:23:58Z","timestamp":1597353838000},"page":"263-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder"],"prefix":"10.1111","volume":"23","author":[{"given":"Andrew J.","family":"Ross","sequence":"first","affiliation":[{"name":"Emotion and Development Branch Department of Health and Human Services National Institute of Mental Health National Institutes of Health Bethesda MD USA"},{"name":"Department of Psychology University of Rochester Rochester NY 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