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Resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) allows non\u2010invasive mapping of brain functional connectivity. The current study used an unbiased voxel\u2010based graph theory analysis of rs\u2010fMRI to investigate the intrinsic brain networks of BD\u2010I patients with and without suicide attempt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 30 BD\u2010I patients with suicide attempt (attempter group), 82 patients without suicide attempt (non\u2010attempter group), and 67 healthy controls underwent rs\u2010fMRI scan, and then global brain connectivity (GBC) was computed as the sum of connections of each voxel with all other gray matter voxels in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the non\u2010attempter group, we found regional differences in GBC values in emotion\u2010encoding circuits, including the left superior temporal gyrus, bilateral insula\/rolandic operculum, and right precuneus (PCu)\/cuneus in the bipolar disorder (BD) attempter group, and these disrupted hub\u2010like regions displayed fair to good power in distinguishing attempters from non\u2010attempters among BD\u2010I patients. GBC values of the right PCu\/cuneus were positively correlated with illness duration and education in the attempter group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate that abnormal connectivity patterns in emotion\u2010encoding circuits are associated with the increasing risk of vulnerability to suicide attempt in BD patients, and global dysconnectivity across these emotion\u2010encoding circuits might serve as potential biomarkers for classification of suicide attempt in BD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13012","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T08:56:21Z","timestamp":1601196981000},"page":"474-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Alterations in resting\u2010state global 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