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To extend these findings, we investigated functional connectivity among these regions in first\u2010episode manic participants who remitted after 8\u00a0weeks of treatment compared to those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two participants with bipolar disorder (60% female) during their first manic episode were recruited and received 8\u00a0weeks of treatment. Twenty\u2010one remitted following treatment. Participants completed fMRI scans, at baseline and following 8\u00a0weeks of treatment, while performing a continuous performance task with emotional and neutral distractors. A healthy comparison group (n\u00a0=\u00a041) received fMRI evaluations at the same intervals. Differences in functional connectivity of the amygdala and caudate with the rostral anterior cingulate and ventrolateral prefrontal cortices at baseline (and changes in functional connectivity following treatment) were modeled between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, non\u2010remitters showed an increase in positive connectivity between right anterior cingulate and caudate and a loss of negative connectivity between right anterior cingulate and amygdala, compared to healthy participants. Individuals who remitted following treatment showed an increase in negative connectivity between amygdala and left anterior cingulate 8\u00a0weeks following treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results provide evidence of alterations in anterior cingulate amygdala and caudate functional connectivity in bipolar disorder non\u2010remitters during a first manic episode and changes in anterior cingulate functional connectivity associated with remission suggesting targets to predict treatment response.<\/jats:p><jats:p>Registered at ClinicalTrials.Gov; Functional and Neurochemical Brain Changes in First\u2010episode Bipolar Mania. NCT00609193. URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00609193?term=strakowskirank=1\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00609193?term=strakowskirank=1<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13025","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T13:47:42Z","timestamp":1603374462000},"page":"500-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-3308","authenticated-orcid":false,"given":"Elizabeth T. 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