{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:40:41Z","timestamp":1791294041992,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T00:00:00Z","timestamp":1610236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["12T\u2010005"],"award-info":[{"award-number":["12T\u2010005"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Previous work suggests supplementation with omega\u20103 polyunsaturated fatty acids (PUFAs) may improve mood symptoms in bipolar disorder (BD) although findings remain unclear. In this study, we assess the efficacy of omega\u20103 PUFA administration for prophylaxis in BD using a clinical trial design over 52\u2010weeks (ClinicalTrials.gov Identifier: NCT04210804).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Individuals with BD (n\u00a0=\u00a080) were randomised to receive placebo (n\u00a0=\u00a040) or 1\u00a0g eicosapentaenoic acid (EPA) plus 1\u00a0g docosahexaenoic acid (DHA; n\u00a0=\u00a040) adjunctively for 52\u2010weeks. The primary outcome measure comprised the number of mood episode relapses including hospital admissions and medication changes experienced. Secondary outcome measures included time to first mood episode relapse and change in psychometric measures of depression and elation (Hamilton Depression Rating Scale and Young Mania Rating Scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>No significant differences in the number of mood episode relapses (<jats:italic>U<\/jats:italic>\u00a0=\u00a0490.00, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.14) or the number of individuals requiring admission to hospital (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.67, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.41) or medication adjustment in the omega\u20103 PUFA compared to the placebo group were noted. Time to relapse was not significantly different between groups (Log Rank <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.52). Change in Young Manic Rating Scale (<jats:italic>F<\/jats:italic>(3.12, 152.86)\u00a0=\u00a02.71, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05) was significantly different between treatment groups over 12\u2010months, with scores at 9\u2010months and 12\u2010months significantly lower than those at 3\u2010months in the omega\u20103 group and not in the placebo group. Change in Hamilton Depression Rating Scale, Global Clinical Impression and Global Assessment of Functioning were not different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite a minor reduction in hypomania scores in the omega\u20103 PUFA group compared to placebo, we find little evidence that the supplementation of omega\u20103\u2010PUFAs exhibits prophylactic benefit in BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13037","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T17:33:50Z","timestamp":1608399230000},"page":"697-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A 52\u2010week prophylactic randomised control trial of omega\u20103 polyunsaturated fatty acids in bipolar disorder"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-119X","authenticated-orcid":false,"given":"Genevieve","family":"McPhilemy","sequence":"first","affiliation":[{"name":"The Centre for Neuroimaging &amp; Cognitive Genomics (NICOG) Clinical Neuroimaging Lab NCBES Galway Neuroscience Centre College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Ireland Republic of Ireland"},{"name":"Health Research Board \u2010 Clinical Research Facility Galway National University of Ireland Galway and University Hospital Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fintan","family":"Byrne","sequence":"additional","affiliation":[{"name":"The Centre for Neuroimaging &amp; Cognitive Genomics (NICOG) Clinical Neuroimaging Lab NCBES Galway Neuroscience Centre College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Ireland Republic of Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairead","family":"Waldron","sequence":"additional","affiliation":[{"name":"Health Research Board \u2010 Clinical Research Facility Galway National University of Ireland Galway and University Hospital Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Hibbeln","sequence":"additional","affiliation":[{"name":"Section on Nutritional Neurosciences Laboratory of Membrane Biochemistry and Biophysics National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McDonald","sequence":"additional","affiliation":[{"name":"The Centre for Neuroimaging &amp; Cognitive Genomics (NICOG) Clinical Neuroimaging Lab NCBES Galway Neuroscience Centre College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Ireland Republic of Ireland"},{"name":"Health Research Board \u2010 Clinical Research Facility Galway National University of Ireland Galway and University Hospital Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hallahan","sequence":"additional","affiliation":[{"name":"The Centre for Neuroimaging &amp; Cognitive Genomics (NICOG) Clinical Neuroimaging Lab NCBES Galway Neuroscience Centre College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Ireland Republic of Ireland"},{"name":"Health Research Board \u2010 Clinical Research Facility Galway National University of Ireland Galway and University Hospital Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10719785"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"39","article-title":"Efficacy of omega\u20103 fatty acids in mood disorders \u2013 a systematic review and metaanalysis","volume":"42","author":"Kraguljac NV","year":"2009","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06634"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10r06710"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.160242"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.1.46"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.5.407"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.182734"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2006.07.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.056"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318266854c"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00799.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1219b"},{"key":"e_1_2_8_16_1","volume-title":"Diagnostic Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_8_19_1","volume-title":"ECDEU Assessment Manual for Psychopharmacology: Revised","author":"Guy W","year":"1976"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(95)71666-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160606210811"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2015.0132"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.13037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bdi.13037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.13037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:23:22Z","timestamp":1692570202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.13037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,10]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/bdi.13037"],"URL":"https:\/\/doi.org\/10.1111\/bdi.13037","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,10]]},"assertion":[{"value":"2021-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}