{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:27:09Z","timestamp":1761920829059,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K01MH097769","R01MH093666","R01MN093676"],"award-info":[{"award-number":["K01MH097769","R01MH093666","R01MN093676"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment\u2010related changes in emotion processing networks in youth at familial high risk for bipolar disorder (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Youth, ages 9\u201317, were randomly assigned to family\u2010focused therapy for high\u2010risk youth (FFT\u2010HR) or an active comparison treatment, Enhanced Care (EC). Before and after these 4\u2010month treatments, participants underwent fMRI while viewing happy, fearful, and calm facial expressions. Twenty youth in FFT\u2010HR and 20 in EC were included in analyses of pre\u2010 to post\u2010treatment changes in activation across the whole brain. Significant clusters were assessed for correlation with mood symptom improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the dorsolateral prefrontal cortex (DLPFC), activation increased from pre\u2010 to post\u2010treatment in the FFT\u2010HR group and decreased in the EC group. Insula activation decreased in the FFT\u2010HR group and did not change in the EC group. Across both treatments, decreasing activation in the hippocampus and amygdala was correlated with pre\u2010 to post\u2010treatment improvement in hypomania, while increasing activation in the DLPFC was correlated with pre\u2010 to post\u2010treatment improvement in depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Psychosocial treatment addresses abnormalities in emotion regulation networks in youth at high risk for BD. Increased prefrontal cortex activation suggests enhanced emotion regulation from pre\u2010 to post\u2010treatment with FFT\u2010HR. Improvements in family interactions may facilitate the development of prefrontal resources that provide protection against future mood episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13045","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:22:33Z","timestamp":1610695353000},"page":"604-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neural changes in youth at high risk for bipolar disorder undergoing family\u2010focused therapy or psychoeducation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-7825","authenticated-orcid":false,"given":"Amy S.","family":"Garrett","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiki 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