{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:24:42Z","timestamp":1786443882069,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["083924"],"award-info":[{"award-number":["083924"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of fish oil (FO), a source of the omega\u20103 polyunsaturated fatty acids (<jats:italic>n<\/jats:italic>\u20103 PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion\u2010generated corticolimbic functional connectivity in depressed youth at high risk for developing bipolar I disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine antidepressant\u2010free youth with a current depressive disorder diagnosis and a biological parent with bipolar I disorder were randomized to 12\u2010week double\u2010blind treatment with FO or placebo. At baseline and endpoint, fMRI (4 Tesla) scans were obtained while performing a continuous performance task with emotional and neutral distractors (CPT\u2010END). Seed\u2010to\u2010voxel functional connectivity analyses were performed using bilateral orbitofrontal cortex (OFC) and amygdala (AMY) seeds. Measures of depression, mania, global symptom severity, and erythrocyte fatty acids were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Erythrocyte EPA+DHA composition increased significantly in the FO group (+47%, <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.0001) but not in the placebo group (\u221210%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.11). Significant group by time interactions were found for functional connectivity between the left OFC and the left superior temporal gyrus (STG) and between the right AMY and right inferior temporal gyrus (ITG). OFC\u2010STG connectivity increased in the FO group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001) and decreased in the placebo group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0019), and AMY\u2010ITG connectivity decreased in the FO group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0014) and increased in the placebo group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). In the FO group, but not placebo group, the decrease in AMY\u2010ITG functional connectivity correlated with decreases in Childhood Depression Rating Scale\u2010Revised and Clinical Global Impression\u2010Severity Scale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In depressed high\u2010risk youth FO supplementation alters emotion\u2010generated corticolimbic functional connectivity which correlates with changes in symptom severity ratings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13110","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T19:06:32Z","timestamp":1625252792000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fish oil supplementation alters emotion\u2010generated corticolimbic functional connectivity in depressed adolescents at high\u2010risk for bipolar I disorder: A 12\u2010week placebo\u2010controlled fMRI 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