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Previous neuroimaging studies across mood states of BD<jats:sub>AYA<\/jats:sub> are scarce and often examined limited brain regions potentially prohibiting detection of other important regions. We used a data\u2010driven whole\u2010brain Intrinsic Connectivity Distribution (ICD) approach to investigate dysconnectivity hubs across mood states in BD<jats:sub>AYA<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional magnetic resonance imaging whole\u2010brain ICD data were investigated for differences across four groups: BD<jats:sub>AYA<\/jats:sub>\u2010depressed (<jats:italic>n<\/jats:italic>\u00a0=\u00a022), BD<jats:sub>AYA<\/jats:sub>\u2010euthymic (<jats:italic>n<\/jats:italic>\u00a0=\u00a045), BD<jats:sub>AYA<\/jats:sub>\u2010elevated (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), and healthy controls (HC, <jats:italic>n<\/jats:italic>\u00a0=\u00a0111). Clusters of ICD differences were assessed for regional dysconnectivity and mood symptom relationships. Analyses were also performed for BD<jats:sub>AYA<\/jats:sub> overall (vs. HC) ICD differences persisting across mood states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ICD was higher in the BD<jats:sub>AYA\u2010<\/jats:sub> depressed group than other groups in bilateral ventral\/rostral\/dorsal prefrontal cortex (PFC) and right lenticular nucleus (LN) (<jats:italic>p<\/jats:italic><jats:sub>corrected<\/jats:sub>\u00a0&lt;0.05). In BD<jats:sub>AYA<\/jats:sub>\u2010depressed, functional connectivity (FC) was increased between these regions with their contralateral homologues and PFC\u2010medial temporal FC was more negative (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.005). PFC\u2010related findings correlated with depression scores (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). The overall BD<jats:sub>AYA<\/jats:sub> group showed ICD increases in more ventral left PFC and right cerebellum, present across euthymia and acute mood states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This ICD approach supports a PFC hub of inter\u2010 and intra\u2010hemispheric frontotemporal dysconnectivity in BD<jats:sub>AYA<\/jats:sub> with potential trait features and disturbances of higher magnitude during depression. Hubs were also revealed in LN and cerebellum, less common foci of BD research. The hubs are potential targets for early interventions to detect, prevent, and treat BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13144","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:42:32Z","timestamp":1634766152000},"page":"412-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A graph theory\u2010based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-7372","authenticated-orcid":false,"given":"Danielle A.","family":"Goldman","sequence":"first","affiliation":[{"name":"Interdepartmental Neuroscience Program Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-9776","authenticated-orcid":false,"given":"Anjali","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Neurology and Neurobiology Research Unit Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-4034","authenticated-orcid":false,"given":"Lejla","family":"Colic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychiatry and Psychotherapy Jena University Hospital  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5091-6410","authenticated-orcid":false,"given":"Luca","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihoon A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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