{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:39:08Z","timestamp":1777088348169,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bipolar depression is the most prevalent phase of bipolar disorder (BD). There is a risk of inducing treatment\u2010emergent affective switches (TEAS) with antidepressants (ADs). Hence, clinical guidelines do not recommend their use in monotherapy. Cariprazine is a dopamine\u2010serotonin partial agonist, with a recent FDA approval as a monotherapy for BD type 1 (BD\u2010I) depression. To our knowledge, there is no significant evidence of cariprazine\u2010induced TEAS in bipolar depression. We describe three clinical cases of patients admitted to our acute psychiatric ward who developed manic episodes after the introduction of low doses of cariprazine. Two of the patients met the DSM\u20105 criteria for BD\u2010I, and one for schizoaffective disorder, bipolar type. All patients were initially treated with low doses of cariprazine (1.5\u00a0mg) during a depressive phase. All three cases were simultaneously treated with mood stabilizers, regardless of which they switched to a manic episode when cariprazine was initiated. In our review of previous studies assessing the efficacy and side effects profile of cariprazine in BD\u2010I, TEAS have not been found to be significant. However, according to our experience, cariprazine may induce affective switches in BD\u2010I patients. Patients and psychiatrists should receive information regarding early warning symptoms and monitor possible cariprazine\u2010induced mood switching.<\/jats:p>","DOI":"10.1111\/bdi.13156","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T15:13:37Z","timestamp":1637334817000},"page":"457-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cariprazine\u2010induced mania: A case series report"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-0396","authenticated-orcid":false,"given":"Mar\u00eda T.","family":"Pons\u2010Cabrera","sequence":"first","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-3738","authenticated-orcid":false,"given":"Roberto","family":"Palacios\u2010Garr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Mental Health, and Addiction, GSS\u2013Hospital Santa Maria  Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Tard\u00f3n\u2010Senabre","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabatha","family":"Fern\u00e1ndez\u2010Plaza","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriol","family":"Marco\u2010Estrada","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia 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Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluc","family":"Colomer","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Druetta","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia 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en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red en salud Mental (CIBERSAM)  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Pacchiarotti","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n 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