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We used random\u2010effects meta\u2010analysis to calculate the standardized difference (Hedges\u2019 g) in pre\u2010post change scores between smartphone intervention and control conditions. The study was pre\u2010registered with PROSPERO (CRD42021226668).<\/jats:p><\/jats:sec>Results<\/jats:title>The literature search identified 6034 studies. Thirteen articles fulfilled the selection criteria. We included seven RCTs and performed meta\u2010analyses comparing the pre\u2010post change in depressive and (hypo)manic symptom severity, functioning, quality of life, and perceived stress between smartphone interventions and control conditions. There was significant heterogeneity among studies and no meta\u2010analysis reached statistical significance. Results were also inconclusive regarding affective relapses and psychiatric readmissions. All studies reported positive user\u2010engagement indicators.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We did not find evidence to support that smartphone interventions may reduce the severity of depressive or manic symptoms in BD. The high heterogeneity of studies supports the need for expert consensus to establish ideally how studies should be designed and the use of more sensitive outcomes, such as affective relapses and psychiatric hospitalizations, as well as the quantification of mood instability. The ISBD Big Data Task Force provides preliminary recommendations to reduce the heterogeneity and achieve more valid evidence in the field.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13243","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T17:49:02Z","timestamp":1657907342000},"page":"580-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Smartphone\u2010based interventions in bipolar disorder: Systematic review and meta\u2010analyses of efficacy. A position paper from the International Society for Bipolar Disorders (ISBD<\/scp>) Big Data Task Force"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-4054","authenticated-orcid":false,"given":"Gerard","family":"Anmella","sequence":"first","affiliation":[{"name":"Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-6444","authenticated-orcid":false,"given":"Maria","family":"Faurholt\u2010Jepsen","sequence":"additional","affiliation":[{"name":"Copenhagen Affective Disorder research Center (CADIC) Psychiatric Center Copenhagen Copenhagen 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