{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:42:41Z","timestamp":1789692161849,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1087560"],"award-info":[{"award-number":["APP1087560"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["COCKPI\u2010T (Co\u2010Create Knowledge for Pharma Innovatio"],"award-info":[{"award-number":["COCKPI\u2010T (Co\u2010Create Knowledge for Pharma Innovatio"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite homogenous clinical presentations between bipolar and unipolar disorders, there are distinct neurobiological differences. Chronicity of illness may be a factor impacting and sustaining certain neural features. The goal of this study was to investigate common and shared neural mechanisms underlying mood disorders, and possible sustained neural changes relating to illness chronicity by investigating a cohort of euthymic patients with bipolar disorder (BD), unipolar depression who had responded to treatment (treatment\u2010sensitive depression, TSD), and a chronically treatment\u2010resistant depressed (TRD) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and seventy\u2010two participants (40 BD, 39 TSD, 40 TRD, and 53 age\u2013gender\u2010matched healthy controls) underwent resting\u2010state fMRI scans. Seed\u2010based and independent component analyses were performed to investigate group differences in resting\u2010state connectivity between the four groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three clinical groups had significantly lower connectivity within the frontoparietal network (FPN) relative to controls. TRD and BD were significantly different from TSD (TRD, BD\u2009&gt;\u2009TSD) but were not significantly different from each other. TRDs were also significantly different from both BD and TSD for salience network connectivity with the posterior cingulate (DMN) and the FPN with frontal pole (DMN). Additionally, the BD group exhibited greater DMN\u2010FPN (sgACC\u2010RDLPFC) connectivity relative to TRD, TSD, and controls, which was correlated with a previous number of depressive episodes, in the BD group only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BD demonstrated shared and differential connectivity features relative to symptomatic TRD and euthymic TSD groups. The increased sgACC\u2010RDLPFC connectivity in BD and its correlation with a number of depressive episodes could be a neural feature associated with illness chronicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13248","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T14:24:31Z","timestamp":1660659871000},"page":"795-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Common and differential neural mechanisms underlying mood disorders"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-4153","authenticated-orcid":false,"given":"Sabina","family":"Rai","sequence":"first","affiliation":[{"name":"Brain Dynamics Centre Westmead Institute for Medical Research, The University of Sydney  Westmead, Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health, Westmead Clinical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre Westmead Institute for Medical Research, The University of Sydney  Westmead, Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-5274","authenticated-orcid":false,"given":"Isabella A.","family":"Breukelaar","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre Westmead Institute for Medical Research, The University of Sydney  Westmead, Sydney New South Wales Australia"},{"name":"School of Psychology University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Barreiros","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre Westmead Institute for Medical Research, The University of Sydney  Westmead, Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health, Westmead Clinical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-7356","authenticated-orcid":false,"given":"Philip","family":"Boyce","sequence":"additional","affiliation":[{"name":"Specialty of Psychiatry The University of Sydney School of Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hazell","sequence":"additional","affiliation":[{"name":"Specialty of Psychiatry The University of Sydney School of Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Radiology Westmead Hospital  New South Wales Australia"},{"name":"Faculty of Medicine and Health, Sydney School of Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin S.","family":"Malhi","sequence":"additional","affiliation":[{"name":"Specialty of Psychiatry The University of Sydney School of Medicine  Sydney New South Wales Australia"},{"name":"Department of Psychiatry, CADE Clinic Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W. 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