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This study examined differences between BD\u2010I and BD\u2010II in a large, global sample of OABD, focusing on general functioning, cognition and somatic burden as these domains are often affected in OABD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional analyses were conducted with data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE\u2010BD) database. The sample included 963 participants aged \u226550\u2009years (714 BD\u2010I, 249 BD\u2010II). Sociodemographic and clinical factors were compared between BD subtypes including adjustment for study cohort. Multivariable analyses were conducted with generalized linear mixed models (GLMMs) and estimated associations between BD subtype and (1) general functioning (GAF), (2) cognitive performance (g\u2010score) and (3) somatic burden, with study cohort as random intercept.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for study cohort, BD\u2010II patients more often had a late onset \u226550\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and more current severe depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041). BD\u2010I patients were more likely to have a history of psychiatric hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and current use of anti\u2010psychotics (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). Multivariable analyses showed that BD subtype was not related to GAF, cognitive g\u2010score or somatic burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BD\u2010I and BD\u2010II patients did not differ in terms of general functioning, cognitive impairment or somatic burden. Some clinical differences were observed between the groups, which could be the consequence of diagnostic definitions. The distinction between BD\u2010I and BD\u2010II is not the best way to subtype OABD patients. Future research should investigate other disease specifiers in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13271","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T04:04:48Z","timestamp":1668485088000},"page":"43-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bipolar I and bipolar\n                    <scp>II<\/scp>\n                    subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (\n                    <scp>GAGE\u2010BD<\/scp>\n                    ) project"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-2579","authenticated-orcid":false,"given":"Alexandra J. 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L.","family":"Kok","sequence":"additional","affiliation":[{"name":"GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry  Amsterdam The Netherlands"},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health research institute, Mental Health  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-5405","authenticated-orcid":false,"given":"Sigfried N. T. 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