{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:10Z","timestamp":1792180630196,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real\u2010world effectiveness of repeated ketamine infusions for treatment\u2010resistant bipolar depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was conducted in a community clinic in Mississauga, Ontario (Canadian Rapid Treatment Centre of Excellence; Braxia Health). In this observational study (NCT04209296), patients with treatment\u2010resistant bipolar I\/II depression (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066) received four sub\u2010anesthetic doses of IV ketamine (0.5\u20130.75\u2009mg\/kg) over a two\u2010week period. Symptoms of depression, suicidality, anxiety, and functioning were assessed with validated self\u2010report measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically and clinically significant antidepressant effects were observed in the overall sample, as measured by the Quick Inventory for Depression Symptomatology\u2010Self Report\u201016 (QIDS\u2010SR\n                      <jats:sub>16<\/jats:sub>\n                      ) with further reductions in depressive symptoms observed after each subsequent infusion (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066; mean QIDS\u2010SR\n                      <jats:sub>16<\/jats:sub>\n                      reduction of 6.08+\/\u22121.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Significant reductions of suicidal thoughts (QIDS\u2010SR\n                      <jats:sub>16<\/jats:sub>\n                      \u2010Suicide Item) and anxiety (Generalized Anxiety Disorder\u20107) were also observed with functional improvements on the Sheehan Disability Scale (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 on all measures). Moreover, the response rate (QIDS\u2010SR\n                      <jats:sub>16<\/jats:sub>\n                      total score decrease \u226550% from baseline) was 35% and remission rate (QIDS\u2010SR\n                      <jats:sub>16<\/jats:sub>\n                      total score \u22645) was 20% after four infusions. Infusions were generally well tolerated with treatment\u2010emergent hypomania observed in only three patients (4.5%) with zero cases of mania or psychosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world effectiveness of IV ketamine for bipolar depression was observed. Repeated doses were associated with greater symptom reduction and adequate tolerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13284","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T15:29:56Z","timestamp":1671031796000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Real\u2010world effectiveness of repeated ketamine infusions for treatment\u2010resistant bipolar depression"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-6061","authenticated-orcid":false,"given":"Farhan","family":"Fancy","sequence":"first","affiliation":[{"name":"Mood Disorders Psychopharmacology Unit University Health Network  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson 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