{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:43:48Z","timestamp":1747183428612,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["Fundo de Incentivo \u00e0 Pesquisa e Eventos (FIPE\/HCP"],"award-info":[{"award-number":["Fundo de Incentivo \u00e0 Pesquisa e Eventos (FIPE\/HCP"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The term \u201cmood stabilizer\u201d is controversial in the literature and criticized for being imprecise and overly inclusive, having its retirement suggested to avoid misuse. Nevertheless, it continues to be employed as it may still carry important meaning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed document analysis for reviewing relevant definitions of mood stabilizer employed in the literature. Then, we clarify the meanings associated with the term by employing evolutionary concept analysis. Based on its results, we present a theoretical model for a mood stabilizer and further match it with evidence gathered from published meta\u2010analyses and other sources for drugs used in the treatment of bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concept analysis unearthed four attributes of a mood stabilizer that were nested into the following ascending hierarchy: \u201cnot worsening,\u201d \u201cacute effects,\u201d \u201cprophylactic effects,\u201d and \u201cadvanced effects.\u201d \u201cProphylactic effects\u201d were often considered the core aspect of a legitimate mood stabilizer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed model uses a hierarchy of attributes that take into account the complexity of the term and help to determine whether a drug is a mood stabilizer. Prophylaxis is pivotal to the concept, whose utility lies in implying a drug able to truly treat bipolar disorder, as opposed to merely targeting symptoms. Consistent use of the term could encourage investigation of drugs that modify long\u2010term outcomes and illness trajectory, instead of simply approaching symptom clusters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13301","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T15:53:36Z","timestamp":1674057216000},"page":"507-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cAddressing the core trait of bipolar disorder\u201d: A concept analysis of mood\u2010stabilizing drugs"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-868X","authenticated-orcid":false,"given":"Lauro Estivalete","family":"Marchionatti","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Graduate Program in Psychiatry and Behavioral Sciences Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Centro de Pesquisa Cl\u00ednica  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Blaya\u2010Rocha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Graduate Program in Psychiatry and Behavioral Sciences Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Centro de Pesquisa Cl\u00ednica  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-6357","authenticated-orcid":false,"given":"Pedro VS","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Graduate Program in Psychiatry and Behavioral Sciences Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Centro de Pesquisa Cl\u00ednica  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1970.01740280013003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.109.463.803"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"108","article-title":"Is clozapine a mood stabilizer?","volume":"56","author":"Zarate CA","year":"1995","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/0048-5713-19960201-08"},{"key":"e_1_2_9_6_1","first-page":"161","volume-title":"Branded in the USA. 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National Health Service.https:\/\/www.nhs.uk\/mental\u2010health\/conditions\/bipolar\u2010disorder\/overview\/. Published 14 March 2019. Accessed 18 July 2021."},{"key":"e_1_2_9_16_1","unstructured":"StovallJ.Patient education: Bipolar disorder (manic depression) (Beyond the Basics). UptoDate.https:\/\/www.uptodate.com\/contents\/bipolar\u2010disorder\u2010manic\u2010depression\u2010beyond\u2010the\u2010basics. Published June 17 2021. 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