{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:26:15Z","timestamp":1790835975504,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21 MH120824"],"award-info":[{"award-number":["R21 MH120824"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate associations of neonatal characteristics and pregnancy complications with bipolar disorder (BPD) in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide cohort study among 2,059,578 non\u2010malformed singleton live\u2010births in Sweden born 1983\u20132004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from 13 up to 34\u2009years of age. We compared BPD risks between exposure categories using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling\u2010controlled analyses among 1,467,819 full siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 14,998 BPD diagnoses. Risk of BPD was 0.74% through 25\u2009years of age. Very\/extremely preterm birth (22 to 31\u2009weeks) was related to increased BPD HRs in sibling\u2010controlled analyses; compared with a gestational age of 37\u2009weeks, adjusted HR (95% CI) for 31, 28, and 22\u2009weeks were, respectively, 1.31 (0.99, 1.74), 2.09 (1.15, 3.79), and 5.74 (1.15, 28.63). Spontaneous but not medically indicated very\/extremely preterm birth was associated with increased risk. Compared with vaginal birth, caesarean section birth was associated with 1.20 (1.08, 1.33) and 1.58 (1.06, 2.36) times higher BPD risk in general and sibling cohorts, respectively. Small\u2010for\u2010gestational age (SGA) birth was related to increased BPD HRs in general cohort and sibling analyses (HRs [95% CI] were 1.22 [1.06, 1.39] and 1.68 [1.13, 2.50], respectively); only term SGA was associated with increased risk. Head circumference\u2010for\u2010gestational age, gestational diabetes, preeclampsia, and placental abruption were not associated with BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Very\/extremely preterm birth, caesarean birth, and SGA are related to BPD incidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13327","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T03:31:20Z","timestamp":1682047880000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations of pregnancy complications and neonatal characteristics with bipolar disorder in the offspring: Nationwide cohort and sibling\u2010controlled studies"],"prefix":"10.1111","volume":"25","author":[{"given":"Rachael J.","family":"Beer","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cnattingius","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine (Solna) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra S.","family":"Susser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University, and New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-5574","authenticated-orcid":false,"given":"Eduardo","family":"Villamor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Global Burden of Disease Collaborative Network.Global Burden of Disease Study 2019 (GBD2019) Results.http:\/\/ghdx.healthdata.org\/gbd\u2010results\u2010tool. 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