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However, heterogeneous results in patients with different disease states and different valences of emotional stimuli have been identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To integrate previous results and elucidate the impact of disease state and stimulus valence, we conducted a systematic literature search for journal articles in the Web of Science Core Collection including MEDLINE databases and employed a coordinate\u2010based\u2010meta\u2010analysis of functional\u2010MRI studies comparing emotion processing in BD\u2010patients with healthy participants\u00a0using seed\u2010based d mapping (SDM) to test for between\u2010subjects\u2010effects. We included 31 studies published before 11\/2022 with a total of\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009766 BD\u2010patients and\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009836 controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with BD showed hyperactivated regions involved in salience processing of emotional stimuli (e.g., the bilateral insula) and hypoactivation of regions associated with emotion regulation (e.g., inferior frontal gyrus) during emotion processing, compared to healthy participants. A more detailed descriptive analysis revealed a hypoactive (anterior) insula in manic BD\u2010patients specifically for negative in comparison to positive emotion processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This meta\u2010analysis corroborates the overall tenor of existing literature that patients with BD show an increased emotional reactivity (hyperactivity of salience\u2010processing regions) together with a lower (cognitive) control (hypoactivity of brain areas associated with emotion regulation) over emotional states. Our analysis suggests reduced interoceptive processing of negative stimuli in mania, pointing out the need for longitudinal within\u2010subject analyses of emotion processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13341","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T23:54:52Z","timestamp":1685404492000},"page":"540-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["How do bipolar disease states affect positive and negative emotion processing? Insights from a meta\u2010analysis on the neural fingerprints of emotional processing"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3041-9246","authenticated-orcid":false,"given":"Katharina","family":"F\u00f6rster","sequence":"first","affiliation":[{"name":"Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-7471","authenticated-orcid":false,"given":"Lara Z.","family":"Maliske","sequence":"additional","affiliation":[{"name":"Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-9943","authenticated-orcid":false,"given":"Matthias","family":"Schurz","sequence":"additional","affiliation":[{"name":"Institute of Psychology and Digital Science Center (DiSC) University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.","family":"Henneberg","sequence":"additional","affiliation":[{"name":"Clinic and Outpatient Clinic of Psychiatry and Psychotherapy University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Dannlowski","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-8782","authenticated-orcid":false,"given":"Philipp","family":"Kanske","sequence":"additional","affiliation":[{"name":"Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology Technische Universit\u00e4t Dresden  Dresden 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