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Answers may optimally be found by studying the longitudinal trajectories of children born to an affected parent. We aimed to differentiate trajectories of global functioning and their sensitive periods from the age of 6 to 17\u2009years in children at familial risk (FHRs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>First<\/jats:italic>, a latent class mixed model analysis (LCMM) was applied to yearly ratings of the Children's Global Assessment Scale (CGAS) from the age of 6 to 17\u2009years in 170 FHRs born to a parent affected by DSM\u2010IV SZ (<jats:italic>N<\/jats:italic>\u2009=\u200937), BP (<jats:italic>N<\/jats:italic>\u2009=\u200982) or MDD (<jats:italic>N<\/jats:italic>\u2009=\u200951). Then, we compared the obtained Classes or trajectories of FHRs in terms of sex, parental diagnosis, IQ, child clinical status, childhood trauma, polygenic risk score (PRS), and outcome in transition to illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LCMM on yearly CGAS trajectories identified a 4\u2010class solution showing markedly different childhood and adolescence dynamic courses and temporal vulnerability windows marked by a functioning decline and a degree of specificity in parental diagnosis. Moreover, IQ, trauma exposure, PRS level, and timing of later transition to illness differentiated the trajectories. Almost half (46%) of the FHRs exhibited a good and stable global functioning trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FHRs\u00a0of major psychiatric disorders show heterogeneous functional decline during development associated with parental diagnosis, polygenic risk loading, and childhood trauma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13386","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T04:36:32Z","timestamp":1699936592000},"page":"265-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heterogeneity in the longitudinal courses of global functioning in children at familial risk of major psychiatric disorders: Association with trauma and familial characteristics"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9999","authenticated-orcid":false,"given":"Alexandre","family":"Bureau","sequence":"first","affiliation":[{"name":"Department of Social and Preventive Medicine, Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Quebec Canada"},{"name":"Cervo Brain Research Centre  Qu\u00e9bec Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Berthelot","sequence":"additional","affiliation":[{"name":"Cervo Brain Research Centre  Qu\u00e9bec Quebec Canada"},{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois\u2010Rivi\u00e8res Department of Nursing Sciences  Trois\u2010Rivieres Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Ricard","sequence":"additional","affiliation":[{"name":"Cervo Brain Research Centre  Qu\u00e9bec Quebec 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