{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:27:10Z","timestamp":1754598430196,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Herpes simplex virus (HSV) infection triggered n\u2010methyl\u2010D\u2010aspartate (NMDA) encephalitis can lead to varied neuropsychiatric manifestations, including movement disorders and manic symptoms. HSV is known to affect the same brain regions as in secondary mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We present a 35\u2010year\u2010old female diagnosed with recurrent depressive disorder (RDD) who developed NMDA encephalitis triggered by HSV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>HSV\u2010triggered NMDA encephalitis led to a manic switch in a woman with RDD on antidepressants, along with the new onset of dyskinetic movements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A neurological insult predisposed our patient to the variable effects of antidepressant drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13393","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T06:50:18Z","timestamp":1700203818000},"page":"192-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unmasking bipolarity in recurrent depressive disorder following herpes simplex virus triggered n\u2010methyl\u2010D\u2010aspartate encephalitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Karthik","family":"Narasimhappa","sequence":"first","affiliation":[{"name":"Department of Psychiatry National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-3834","authenticated-orcid":false,"given":"Harkishan","family":"Mamtani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kshiteeja","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram V.","family":"Holla","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-1191","authenticated-orcid":false,"given":"Sundarnag","family":"Ganjekar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Netravathi","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Kulanthaivelu","sequence":"additional","affiliation":[{"name":"Department of Neuro Imaging and Interventional Radiology National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore 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