{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:09:23Z","timestamp":1769915363527,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the association between maternal early pregnancy body mass index (BMI) and offspring bipolar disorder (BPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide cohort study among 1,507,056 non\u2010malformed singleton live\u2010births in Sweden born 1983\u20132004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from ages 13 to up to 35\u2009years. We compared BPD risks by early pregnancy BMI using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling\u2010controlled analyses among 874,047 full siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 9970 BPD diagnoses. Risk of BPD was 0.72% through 25\u2009years of age. Maternal early pregnancy BMI was positively associated with offspring BPD risk. Compared with normal BMI (18.5\u201324.9), adjusted HR (95% CI) for overweight (BMI 25\u201329.9), obesity grade 1 (BMI 30\u201334.9), and obesity grades 2\u20133 (BMI \u226535) were 1.08 (1.02, 1.15), 1.26 (1.14, 1.40), and 1.31 (1.07, 1.60), respectively. Adjusted HR per unit BMI was 1.015 (95% CI 1.009, 1.021). A similar trend was observed among siblings. Pregnancy and neonatal complications did not substantially mediate the association between maternal obesity (BMI \u226530) and offspring BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal BMI \u226525 is associated with offspring BPD risk in a dose\u2013response manner.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13399","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:18:46Z","timestamp":1700677126000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal early pregnancy body mass index and bipolar disorder in the offspring"],"prefix":"10.1111","volume":"26","author":[{"given":"Rachael J.","family":"Beer","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor Michigan 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