{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:37:47Z","timestamp":1792046267986,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abnormalities in dopamine and norepinephrine signaling are implicated in cognitive impairments in bipolar disorder (BD) and attention\u2010deficit hyperactivity disorder (ADHD). This systematic review by the ISBD Targeting Cognition Task Force therefore aimed to investigate the possible benefits on cognition and\/or ADHD symptoms and safety of established and off\u2010label ADHD therapies in BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included studies of ADHD medications in BD patients, which involved cognitive and\/or safety measures. We followed the procedures of the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis (PRISMA) 2020 statement. Searches were conducted on PubMed, Embase and PsycINFO from inception until June 2023. Two authors reviewed the studies independently using the Revised Cochrane Collaboration's Risk of Bias tool for Randomized trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen studies were identified (<jats:italic>N<\/jats:italic>\u2009=\u20092136), investigating armodafinil (<jats:italic>k<\/jats:italic>\u2009=\u20094, <jats:italic>N<\/jats:italic>\u2009=\u20091581), methylphenidate (<jats:italic>k<\/jats:italic>\u2009=\u20094, <jats:italic>N<\/jats:italic>\u2009=\u200984), bupropion (<jats:italic>k<\/jats:italic>\u2009=\u20094, <jats:italic>n<\/jats:italic>\u2009=\u2009249), clonidine (<jats:italic>k<\/jats:italic>\u2009=\u20091, <jats:italic>n<\/jats:italic>\u2009=\u200970), lisdexamphetamine (<jats:italic>k<\/jats:italic>\u2009=\u20091, <jats:italic>n<\/jats:italic>\u2009=\u200925), mixed amphetamine salts (<jats:italic>k<\/jats:italic>\u2009=\u20091, <jats:italic>n<\/jats:italic>\u2009=\u200930), or modafinil (<jats:italic>k<\/jats:italic>\u2009=\u20092, <jats:italic>n<\/jats:italic>\u2009=\u200997). Three studies investigated cognition, four ADHD symptoms, and 10 the safety. Three studies found treatment\u2010related ADHD symptom reduction: two\u00a0involved methylphenidate and one amphetamine salts. One study found a trend towards pro\u2010cognitive effects of modafinil on some cognitive domains. No increased risk of (hypo)mania was observed. Five studies had low risk of bias, eleven a moderate risk, and one\u00a0a serious risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Methylphenidate or mixed amphetamine salts may improve ADHD symptoms in BD. However, there is limited evidence regarding the effectiveness on cognition. The medications produced no increased mania risk when used alongside mood stabilizers. Further robust studies are needed to assess cognition in BD patients receiving psychostimulant treatment alongside mood stabilizers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.13414","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:18:51Z","timestamp":1709536731000},"page":"216-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of established and off\u2010label ADHD drug therapies for cognitive impairment or attention\u2010deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-1384","authenticated-orcid":false,"given":"Kamilla W.","family":"Miskowiak","sequence":"first","affiliation":[{"name":"Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Department of Psychology University of 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