{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:24:08Z","timestamp":1791836648788,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gut microbial disturbance has been widely confirmed in mood disorders. However, little is known about whether gut microbial characteristics can distinguish major depressive disorder (MDD), bipolar depression (BP\u2010D), and bipolar mania (BP\u2010M).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective case\u2013control study. The composition of gut microbiota was profiled using 16S ribosomal RNA (rRNA) gene sequencing of fecal samples and compared between healthy controls (HC;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946), MDD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951), BP\u2010D (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944), and patients with BP\u2010M (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gut microbial compositions were remarkably changed in the patients with MDD, BP\u2010D, and BP\u2010M. Compared to HC, distinct gut microbiome signatures were found in MDD, BP\u2010D, and BP\u2010M, and some gut microbial changes were overlapping between the three mood disorders. Furthermore, we identified a signature of 7\n                      <jats:italic>operational taxonomic units<\/jats:italic>\n                      (OUT;\n                      <jats:italic>Prevotellaceae<\/jats:italic>\n                      \u2010related OUT22,\n                      <jats:italic>Prevotellaceae<\/jats:italic>\n                      \u2010related OUT31,\n                      <jats:italic>Prevotellaceae<\/jats:italic>\n                      \u2010related OTU770,\n                      <jats:italic>Ruminococcaceae<\/jats:italic>\n                      \u2010related OUT70,\n                      <jats:italic>Bacteroidaceae<\/jats:italic>\n                      \u2010related OTU1536,\n                      <jats:italic>Propionibacteriaceae<\/jats:italic>\n                      \u2010related OTU97,\n                      <jats:italic>Acidaminococcaceae<\/jats:italic>\n                      \u2010related OTU34) that can distinguish patients with MDD from those with BP\u2010D, BP\u2010M, or HC, with area under the curve (AUC) values ranging from 0.910 to 0.996.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results provide the clinical rationale for the discriminative diagnosis of MDD, BP\u2010D, and BP\u2010M by characteristic gut microbial features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13439","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T06:45:00Z","timestamp":1713768300000},"page":"584-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Distinguishing bipolar depression, bipolar mania, and major depressive disorder by gut microbial characteristics"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3709-2099","authenticated-orcid":false,"given":"Taipeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, ZhongDa Hospital; School of Medicine Southeast University  Nanjing Jiangsu China"},{"name":"Department of Medical Psychology Huai'an Third People's Hospital  Huaian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, ZhongDa Hospital; School of Medicine Southeast University  Nanjing Jiangsu China"},{"name":"Department of Medical Psychology Huai'an Third People's Hospital  Huaian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, ZhongDa Hospital; School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, ZhongDa Hospital; School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"You","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, ZhongDa Hospital; 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