{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:25:10Z","timestamp":1790846710129,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder (BD) due to concerns of inducing (hypo)mania, despite limited published evidence on associations between prescribed psychostimulant use and recurrence of mood episodes in BD. The current systematic review and meta\u2010analysis evaluated the emergence of (hypo)manic symptoms in patients with BD receiving prescribed psychostimulants or other pro\u2010cognitive medications in euthymic or depressive states.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was performed of MEDLINE, Embase, and PsychINFO from inception to April 5, 2023 and search of\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      and Clinicaltrialsregister.eu for unpublished data. References of included studies were hand\u2010searched. Randomized trials and prospective longitudinal studies that evaluated psychostimulants and non\u2010stimulant medications recommended for the treatment of ADHD by the Canadian ADHD practice guidelines were included. The review was reported in line with PRISMA guidelines and was preregistered on PROSPERO (CRD42022358588).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After screening 414 unique records, we included 27 studies, of which five reported data that was quantitatively synthesized (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091653). The use of psychostimulants in BD was not associated with increased scores on the Young Mania Rating Scale in patients who were in a euthymic or depressed state (SMD IV \u22120.17; 95% CI, \u22120.40 to 0.06) compared to placebo. There was a high degree of study\u2010level heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200980%). A qualitative synthesis of studies revealed a limited risk of medication\u2010induced manic symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our review provides preliminary evidence to suggest psychostimulants and non\u2010stimulant ADHD medications have a limited risk of precipitating (hypo)mania symptoms. More extensive studies evaluating the safety and efficacy of these medications are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13440","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T20:44:16Z","timestamp":1714164256000},"page":"418-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prescribed psychostimulants and other pro\u2010cognitive medications in bipolar disorder: A systematic review and meta\u2010analysis of recurrence of manic symptoms"],"prefix":"10.1111","volume":"26","author":[{"given":"Andreea","family":"Chiorean","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-1059","authenticated-orcid":false,"given":"Brett D. M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijia","family":"Murong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gonzalez\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kloiber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Toronto Western Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-5750","authenticated-orcid":false,"given":"M. Ishrat","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.114194"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1394"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1322"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-165"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19585969.2022.2042164"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199507000-00010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00175-X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n1003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-008-0807-x"},{"key":"e_1_2_9_13_1","unstructured":"CADDRA.Canadian ADHD Resource Alliance (CADDRA): Canadian ADHD Practice Guidelines.2018."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000723"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08951"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05900gry"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06060981"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000051"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.04.012"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"23","article-title":"The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention\u2010deficit\/hyperactivity disorder","volume":"24","author":"Bond DJ","year":"2012","journal-title":"Ann Clin Psychiatry"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.915800"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1841-6672"},{"key":"e_1_2_9_24_1","unstructured":"National Heart Lung and Blood Institute (NIH).Quality Assessment Tool for Observational Cohort and Cross\u2010Sectional Studies.2021https:\/\/www.nhlbi.nih.gov\/health\u2010topics\/study\u2010quality\u2010assessment\u2010tools"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2009.0030"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e31814b8d3b"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2009.0037"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2000.020108.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2325"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064135"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.06.008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.232"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.013045"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01664-5"},{"issue":"12","key":"e_1_2_9_36_1","first-page":"443","article-title":"Bupropion in the treatment of bipolar disorders: the same old story?","volume":"53","author":"Fogelson DL","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01189.x"},{"issue":"9","key":"e_1_2_9_38_1","first-page":"391","article-title":"A double\u2010blind trial of bupropion versus desipramine for bipolar depression","volume":"55","author":"Sachs GS","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.11.030"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-015-0034-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.050"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.7.910"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00240.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.906"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-198910000-00006"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.2.195"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0758-x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12859"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16040467"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.13440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T23:44:38Z","timestamp":1724629478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.13440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/bdi.13440"],"URL":"https:\/\/doi.org\/10.1111\/bdi.13440","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]},"assertion":[{"value":"2024-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}