{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:51:09Z","timestamp":1772988669132,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10\u201315\u2009years. Several laboratory\u2010measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean chronological age was 40.2 (\u00b112.9). Mean BioAge was 39.1 (\u00b112.4). Mean BioAgeAccel was 0.08 (\u00b11.8). A minority of individuals (15%) had a BioAgeAccel above 2\u2009years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.13480","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T22:59:52Z","timestamp":1722466792000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does\n                    <scp>BioAge<\/scp>\n                    identify accelerated aging in individuals with bipolar disorder? An exploratory study in the\n                    <scp>FACE<\/scp>\n                    \u2010\n                    <scp>BD<\/scp>\n                    cohort"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-1488","authenticated-orcid":false,"given":"Bruno","family":"Etain","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S 1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie OTeN  Paris France"},{"name":"D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique AP\u2010HP, Groupe Hospitalo\u2010Universitaire AP\u2010HP Nord, DMU Neurosciences, H\u00f4pital Fernand Widal  Paris France"},{"name":"Fondation FondaMental  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Marie\u2010Claire","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S 1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie OTeN  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Spano","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S 1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie OTeN  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-6640","authenticated-orcid":false,"given":"Frank","family":"Bellivier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S 1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie OTeN  Paris France"},{"name":"D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique AP\u2010HP, Groupe Hospitalo\u2010Universitaire AP\u2010HP Nord, DMU Neurosciences, H\u00f4pital Fernand Widal  Paris France"},{"name":"Fondation FondaMental  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Translational NeuroPsychiatry Laboratory  Cr\u00e9teil France"},{"name":"AP\u2010HP, H\u00f4pitaux Universitaires Henri Mondor, D\u00e9partement M\u00e9dico\u2010Universitaire de Psychiatrie et d'Addictologie (DMUIMPACT), F\u00e9d\u00e9ration Hospitalo\u2010Universitaire de M\u00e9decine de Pr\u00e9cision en Psychiatrie (FHU ADAPT)  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Gard","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Centre Hospitalier Charles Perrens P\u00f4le de Psychiatrie G\u00e9n\u00e9rale et Universitaire  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Lefrere","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"P\u00f4le de Psychiatrie, Assistance Publique H\u00f4pitaux de Marseille and INT\u2010UMR7289, CNRS Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Belzeaux","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"P\u00f4le Universitaire de Psychiatrie, CHU de Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Department of Emergency Psychiatry and Acute Care CHU Montpellier, IGF, Univ. 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