{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:44Z","timestamp":1788909224222,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Investigating brain network properties in BD patients across mood states can offer insights into the underlying mechanisms of the disorder. This study aimed to explore the topological architecture of functional brain networks in BD and its relationship with clinical variables and genetic\/transcriptomic variations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved 100 BD patients and 95 healthy controls. Researchers used graph theory\u2010based methods to analyze whole\u2010brain functional networks and explore their relationship with clinical variables. We also conducted a neuroimaging\u2010transcription association analysis using the Allen Human Brain Atlas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depressive and manic BD patients exhibited increased local efficiency and decreased global efficiency at the global network level compared to healthy controls. Nodal\u2010level analysis revealed disrupted nodal parameters within specific brain networks, including the fronto\u2010parietal, default mode, and somatomotor networks. Significant correlations were found between nodal properties and cognitive function. All BD groups showed enhanced connectivity strength in rich\u2010club and feeder connections compared to controls. Neuroimaging\u2010transcription analysis identified potential genetic factors related to BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our investigation unveiled shared impairments in the overall topological architecture of functional brain networks across depressive, manic, and euthymic BD. These observed abnormalities were associated with cognitive deficits in BD patients across three mood states. These common deficits, possibly stemming from the segregated changes in structural and functional rich\u2010club connections, might represent trait\u2010like pathophysiological mechanisms inherent to BD. Furthermore, our neuroimaging\u2010transcription association analysis indicates the potential use of brain functional anomalies as endophenotypes in BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.70028","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T03:33:36Z","timestamp":1743478416000},"page":"365-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared Overall Topological Impairments of Functional Brain Networks Across Diverse State of Bipolar Disorder With Relevance to Cognitive Deficits and Genetic and Transcriptomic Variations"],"prefix":"10.1111","volume":"27","author":[{"given":"Yudan","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"Center of Mental Health, Inner Mongolia Autonomous Region  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-2465","authenticated-orcid":false,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003738"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720001865"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2019.180"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176212"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.06.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00935.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13081008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12362"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab356"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517558113"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby138"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12596"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22655"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.10.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01660-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2013.15.3\/osporns"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3874-05.2006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl149"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3539-11.2011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718001150"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2019.0667"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-020-01219-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01247-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.06.013"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903641106"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt290"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23347"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx179"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11405"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.12.005"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac301"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-00989-5"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3214"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502052112"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238411"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000058"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.117"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1328"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203593109"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00324.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13141"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12841"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20997"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.003"},{"issue":"1","key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40345-024-00340-z","article-title":"A Systematic Review of the Biomarkers Associated With Cognition and Mood State in Bipolar Disorder","volume":"12","author":"Perez\u2010Ramos A.","year":"2024","journal-title":"International Journal of Bipolar Disorders"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.1082"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.01.017"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0397-8"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6690"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00857-4"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721001252"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13176"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.01.035"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.10.026"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.70028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T03:45:09Z","timestamp":1756525509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.70028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/bdi.70028"],"URL":"https:\/\/doi.org\/10.1111\/bdi.70028","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2023-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}