{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:20:26Z","timestamp":1783473626632,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This was a 4\u2010year mirror\u2010image study of adult patients diagnosed with bipolar disorder (BD) assessing the effects on treatment continuation and hospitalisation between aripiprazole 1\u2010month (A1M), risperidone\u2010LAI (R\u2010LAI) and the monthly and 3\u2010monthly formulations of paliperidone palmitate (PP1M, PP3M). We aimed to evaluate and compare the use of A1M, R\u2010LAI, and the monthly and 3\u2010monthly formulations of paliperidone palmitate (PP1M, PP3M) by using the change of number and length of hospitalisations 2\u2009years before compared to 2\u2009years after initiation of LAIs for continuers and discontinuers. Secondary outcomes were: (1) discontinuation rates at 2\u2009years and reasons per LAI, (2) time to discontinuation per LAI, and (3) time to first hospitalisation per LAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 122 BD were included; 74 continued LAI treatment at two years. Reasons for discontinuation were poor compliance (50%), ineffectiveness (43.2%), and tolerability issues (13.6%). Both time to individual LAI discontinuation and time to first hospital admission were significantly lower in the R\u2010LAI group. There was a significant overall reduction in the number and length of hospitalisations two years before and after LAI initiation, although multivariate logistic regression analysis showed that A1M, PP1M and R\u2010LAI were associated with an increased risk (OR\u2009=\u20091.89, 95% CI\u2009=\u20091.54\u20133.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015; OR\u2009=\u20091.63, 95% CI\u2009=\u20091.29\u20132.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022; OR\u2009=\u20093.08, 95% CI\u2009=\u20091.48\u20136.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008, respectively) of bed usage compared to PP3M. Last, study completers showed a considerable drop of 79% in number of hospital admissions and 83% in bed days (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) as opposed to non\u2010completers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Study findings suggest that long\u2010acting antipsychotics such as A1M, PP1M, and particularly PP3M are associated with high retention and lower hospitalisation rates after 2\u2009years of treatment in patients with BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70080","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:46:34Z","timestamp":1770119194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Multicentre, 4\u2010Year Mirror\u2010Image Study Comparing the Effectiveness of Long\u2010Acting Injectable Antipsychotics in the Treatment of Bipolar Disorder: Results From the\n                    <scp>LAICO<\/scp>\n                    Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-7698","authenticated-orcid":false,"given":"Juan Antonio","family":"Garc\u00eda\u2010Carmona","sequence":"first","affiliation":[{"name":"Department of Neurology Santa Lucia University Hospital  Murcia Spain"},{"name":"Group of Clinical and Experimental Pharmacology Institute for Biomedical Research of Murcia (IMIB)  Murcia Spain"},{"name":"Faculty of Health Sciences University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Barnett","sequence":"additional","affiliation":[{"name":"West London National Health System (NHS) Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Pilar","family":"Campos\u2010Navarro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Santa Luc\u00eda University Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Mason","sequence":"additional","affiliation":[{"name":"West London National Health System (NHS) Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Simal\u2010Aguado","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pappa","sequence":"additional","affiliation":[{"name":"West London National Health System (NHS) Trust  London UK"},{"name":"Department of Brain Sciences, Faculty of Medicine Imperial College of London  London 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