{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:22:23Z","timestamp":1790662943740,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["QUE 20\u2010026"],"award-info":[{"award-number":["QUE 20\u2010026"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bipolar disorder is a chronic, complex mental health condition. Chronic Care Models were developed to treat chronic medical conditions in primary care. Several clinical trials have assessed their effects in treating individuals with bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review identified randomized controlled trials that tested interventions utilizing at least three of the five Chronic Care Model clinical elements. Random effects meta\u2010analysis assessed impact on six outcome domains: overall mental health, mania, depression, mental health\u2010related quality of life, physical health\u2010related quality of life, and treatment costs. Risk of bias for individual trials and confidence in the point estimate for outcome domains were determined following the Cochrane methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight randomized controlled trials were identified, resulting in six meta\u2010analyses of two to eight trials each. The single\u2010blind methodology resulted in a high overall risk of bias for each trial. Statistically significant benefit was seen for overall mental health (standardized mean difference (SMD)\u2009=\u20090.28, 95% CI\u2009=\u20090.13\u20130.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), mania (SMD\u2009=\u20090.16, 95% CI\u2009=\u20090.01\u20130.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), and mental health\u2010related quality of life (SMD\u2009=\u20090.24, 95% CI\u2009=\u20090.08\u20130.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). No evidence of an effect was seen for depression, physical health\u2010related quality of life, or costs. Confidence was moderate for overall mental health outcome, mania, depression, and mental health\u2010related quality of life; low for physical health\u2010related quality of life; and very low for costs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Trials in diverse health care systems indicate that Chronic Care Model elements may improve mental health outcomes for bipolar disorder. This meta\u2010analysis highlights the need for research to further explore the effectiveness and implementation of these models of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70085","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:24:19Z","timestamp":1770729859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Collaborative Chronic Care Models for Bipolar Disorder: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-9918","authenticated-orcid":false,"given":"Mark S.","family":"Bauer","sequence":"first","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6833","authenticated-orcid":false,"given":"Christopher J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"US Department of Veterans Affairs (VA) Boston Healthcare System Center for Health Optimization and Research  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/aitc202207190"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12423"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415594427"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010014\u20100499\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.64719\/pb.4494"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-12-199712150-00008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/3350391"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.28.1.75"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.15.1909"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1775"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010022\u201002117\u2010w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006525.pub2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11111616"},{"key":"e_1_2_8_17_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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