{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:48:04Z","timestamp":1791859684619,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR002379"],"award-info":[{"award-number":["KL2 TR002379"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i), initially developed for type 2 diabetes, have shown promise in improving renal outcomes in patients with and without diabetes. However, their effect on lithium\u2010associated kidney dysfunction remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This historical cohort study included patients from Mayo Clinic (2001\u20132023) with mood disorders who received lithium for \u2265\u20096\u2009months and later used SGLT2i for \u2265\u20091\u2009month. Data on SGLT2i use and lithium treatment were extracted from electronic health records. Serum creatinine values were used to calculate estimated glomerular filtration rate (eGFR) trajectories. Linear mixed\u2010effects models with piecewise linear splines were used to estimate eGFR slopes before and after SGLT2i initiation, adjusted for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six patients (mean age 57.4\u2009years, 46.4% female), predominantly with bipolar disorder (87.5%), were included. The mean eGFR, measured nearest to SGLT2i initiation, was 77.9\u2009\u00b1\u200926.0\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , and the mean duration of SGLT2i use was 19.5\u2009\u00b1\u200917.8\u2009months. Before SGLT2i initiation, eGFR declined at a rate of \u22121.43\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      per year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After initiation, eGFR increased by 0.69\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      per year, reflecting a\u2009+\u20092.13 change (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Sensitivity analyses, including only patients on lithium at SGLT2i initiation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) or who had &gt;\u20091\u2009year of SGLT2i use (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) showed similar, though non\u2010significant, changes in slopes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SGLT2i treatment was associated with a significant improvement in eGFR trajectory in patients with mood disorders who received long\u2010term lithium therapy. These findings suggest a potential role for SGLT2is in mitigating lithium\u2010associated kidney dysfunction and highlight the need for randomized controlled trials in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70094","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:30:58Z","timestamp":1772991058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>SGLT2<\/scp>\n                    Inhibitors Associated With Improved Kidney Function in Lithium\u2010Treated Patients With Mood Disorders: A Real\u2010World Historical Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Mete","family":"Ercis","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Psychology Mayo Clinic  Rochester Minnesota 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