{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:04:35Z","timestamp":1781078675319,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R37MH100041"],"award-info":[{"award-number":["R37MH100041"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Bipolar Disorder (BD)\u2014characterized by mania, affective lability, and elevated psychosis risk\u2014is associated with sustained attention deficits. However, evidence regarding performance on the AX\u2010Continuous Performance test task (AX\u2010CPT), a task reliably impaired in schizophrenia\u2010spectrum psychosis, is mixed. This study examined whether individual differences in mania\/affective lability risk and psychosis risk, across cohorts of BD and BD\u2010at\u2010risk individuals, were associated with altered AX\u2010CPT performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The standard measures d'context and A\u2010cue bias quantified AX\u2010CPT performance. Factors from the Mood Spectrum Self Report (MOODS\u2010SR\u2010L) indexed lifetime mania\/affective lability risk (psychomotor activation, suicidality, and mixed instability) and lifetime psychosis risk. Linear regressions were performed for dimensional continuous aims (Aims 1\u20132) for both d'context and A\u2010cue bias. Tests between BD with low and high\u2010risk groups (Aims 3\u20134) were completed with ANCOVAs for both AX\u2010CPT output measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the final sample of euthymic BD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) and at\u2010risk individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009121), higher levels of psychosis and mania\/affective lability risk were associated with reduced target discrimination (d'context; absolute\n                      <jats:italic>t<\/jats:italic>\n                      's\u2009&gt;\u20092.015,\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009&lt;\u20090.047), but not with altered A\u2010cue bias. Group comparisons showed no significant differences for either AX\u2010CPT measure. Associations with d'context from Aims 1\u20132 remained after covarying for current depressive symptoms but were removed when covarying for current mania severity (absolute\n                      <jats:italic>t<\/jats:italic>\n                      's\u2009&lt;\u20091.26, all\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009&gt;\u20090.203).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Target discrimination deficits were associated dimensionally with psychosis and mania\/affective lability risk but not categorically with BD diagnosis. This suggests scope for dimensional risk models for understanding sustained attention deficits in BD and at\u2010risk individuals and highlights contributions of mania\/affective lability and psychosis risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70129","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:39:58Z","timestamp":1781008798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the\n                    <scp>AX<\/scp>\n                    \u2010Continuous Performance Task Paradigm"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8109-8497","authenticated-orcid":false,"given":"Meghan","family":"Fiske","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania 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