{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:28Z","timestamp":1786119268985,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bipolar disorder (BD) is a chronic mental health condition characterized by extreme mood swings, which significantly affects both the individual and their family system. Given the psychosocial impact of BD on families, family interventions (FI) have emerged as a promising approach to improve treatment outcomes. This review explores the effectiveness of FI in managing BD, focusing on various intervention types, their outcomes, and clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review followed PRISMA guidelines and registered with PROSPERO (registration number: CRD42023410879). We included studies involving adults diagnosed with BD and their family members, focusing on family\u2010based interventions. Studies were identified through systematic searches in five bibliographic databases and managed using Covidence 2.0. Data extraction and synthesis included primary and secondary outcomes related to clinical, behavioral, and lifestyle measures. Risk of bias was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool for quasi\u2010experimental studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Family\u2010focused interventions were found to reduce relapse rates, enhance medication adherence, and improve family communication. Psychoeducational interventions also demonstrated a significant reduction in symptom severity and hospitalization rates. However, findings regarding the long\u2010term sustainability of these outcomes were mixed, and some interventions showed limited generalizability across diverse family structures and cultural contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FIs are critical in treating BD by improving both clinical and relational outcomes. However, the heterogeneity of family structures and cultural factors calls for more tailored approaches to ensure long\u2010term efficacy. Future research should focus on developing culturally sensitive interventions and exploring the mechanisms by which family dynamics influence treatment adherence and recovery in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70135","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:54:10Z","timestamp":1781787250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Family Interventions in Bipolar Disorder: A Systematic Review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-1211","authenticated-orcid":false,"given":"Madeha","family":"Umer","sequence":"first","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Institute of Medical Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0031-4913","authenticated-orcid":false,"given":"L. 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Bloomberg Faculty of Nursing University of Toronto  Toronto Ontario Canada"},{"name":"Sinai Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-4840","authenticated-orcid":false,"given":"Farooq","family":"Naeem","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-6450","authenticated-orcid":false,"given":"Benoit","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine University of Toronto  Toronto Ontario 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