{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:32:32Z","timestamp":1792200752532,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The prevalence of tobacco smoking and high nicotine dependence (ND) in bipolar disorder (BD) is higher than in the general population but lower than in schizophrenia. This study aims to analyse the relationship of smoking behaviours, including age at onset of daily smoking (AODS), with age at onset of BD and course\u2010of\u2010illness variables \u2013particularly recurrent suicide attempt\u2013 in a community sample of BD patients, also compared in their smoking behaviour variables with a sample of non\u2010psychiatric adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Samples of 108 patients with BD and 290 non\u2010psychiatric adults were compared in their smoking habit. High ND was defined by a score of \u2265\u20096 on the Fagerstr\u00f6m Test for Nicotine Dependence. Logistic regression analyses were employed to identify factors associated with daily smoking and high ND. Hazard curves were used to compare AODS between patients and controls and, among patients, age of BD onset between smokers and non\u2010smokers. Within\u2010subject survival times \u2013AODS and the age at onset of BD symptoms\u2013 were compared with a multi\u2010state illness\u2010death model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, BD patients showed higher prevalences of current daily smoking (44% vs. 34%) and high ND (25% vs. 9%); and lower smoking cessation rates (23% vs. 38%). Among BD patients, recurrent suicide attempt showed a strong independent association with both daily smoking and high ND. AODS was later in BD patients than the control group. Among patients, illness onset was earlier in smokers and AODS was earlier than illness onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Addressing tobacco consumption should be an integral component of BD prevention and treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70149","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:19:52Z","timestamp":1784197192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Smoking Initiation, Age at Onset of Symptoms and Suicide Attempts Among Patients With Bipolar Disorder: Comparisons With Non\u2010Psychiatric Adults"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-1627","authenticated-orcid":false,"given":"Manuel","family":"Gurpegui","sequence":"first","affiliation":[{"name":"Granada Centre for Psychiatric Studies  Granada Spain"},{"name":"Multicentre CTS\u2010549 Research Group (Psychiatry and Neurosciences), Junta de Andaluc\u00eda  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-2189","authenticated-orcid":false,"given":"Luis","family":"Guti\u00e9rrez\u2010Rojas","sequence":"additional","affiliation":[{"name":"Multicentre CTS\u2010549 Research Group (Psychiatry and Neurosciences), Junta de Andaluc\u00eda  Granada Spain"},{"name":"Department of Psychiatry University of Granada  Granada Spain"},{"name":"Psychiatry Service Cl\u00ednico San Cecilio University Hospital  Granada 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