{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:13:30Z","timestamp":1786119210990,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102,616\/Z"],"award-info":[{"award-number":["102,616\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mood and\/or affective instability and circadian rhythm disruptions are increasingly recognised in psychiatric disorders, notably bipolar disorder (BD), but their interrelationship remains unclear. By definition, both have an integral temporal component and, as such, measuring them longitudinally and remotely is desirable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed the feasibility and value of digital devices to capture mood and subjective state (affect) instability and daily rest\u2010activity patterns over a 10\u2010week period in two groups of participants. The first group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) scored &gt;\u20097 on the Mood Disorder Questionnaire (MDQ) (\u2018high MDQ\u2019), indicating a history of mood elevation and increased risk for BD. They were compared with a group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) scoring &lt;\u20095 on the MDQ (\u2018low MDQ\u2019). Over the 10\u2010week period, mood was rated daily, clinical ratings of depression, mania and anxiety were captured weekly, and a GENEActiv actigraph was worn to collect rest\u2010activity pattern data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main findings were that (1) MDQ score predicted instability in mood and subjective state; (2) high MDQ score was associated with greater negative affect, mood symptoms and altered circadian activity profiles compared with low MDQ; and (3) mood and subjective state instability appeared unrelated to circadian indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that (1) remote monitoring of these domains is feasible and valuable; (2) selection of participants based on MDQ score is useful for studying mood and affective instability; and (3) this approach has potential utility for clinical and experimental medicine studies assessing interventions targeting mood dysregulation and affective instability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70156","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:47:07Z","timestamp":1784270827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Mood Instability and Circadian Rest\u2010Activity Patterns Using Digital Remote Monitoring and Actigraphy in Participants at Risk for Bipolar Disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-3014","authenticated-orcid":false,"given":"Priyanka","family":"Panchal","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-8143","authenticated-orcid":false,"given":"Natalie","family":"Nelissen","sequence":"additional","affiliation":[{"name":"DWP Digital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-8558","authenticated-orcid":false,"given":"Niall M.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-8721","authenticated-orcid":false,"given":"Lauren Z.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6965-0700","authenticated-orcid":false,"given":"Kate E. A.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"},{"name":"Oxford Health NHS Foundation Trust, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-1126","authenticated-orcid":false,"given":"Paul J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"},{"name":"Oxford Health NHS Foundation Trust, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-9884","authenticated-orcid":false,"given":"Matthew","family":"Rushworth","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-4835","authenticated-orcid":false,"given":"Dejan","family":"Draschkow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"},{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-5960","authenticated-orcid":false,"given":"John","family":"Geddes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-2802","authenticated-orcid":false,"given":"Anna C.","family":"Nobre","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"},{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-8335","authenticated-orcid":false,"given":"Catherine J.","family":"Harmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15040414"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.09.043"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0014173"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002407"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.01.053"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/emo0000759"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11295"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12367"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.006"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"12","article-title":"Cognitive Impairments in Major Depression and Bipolar Disorders","volume":"4","author":"Harvey P. 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