{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:06:56Z","timestamp":1788937616580,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH113230"],"award-info":[{"award-number":["R01MH113230"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH083968"],"award-info":[{"award-number":["R01MH083968"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013893","name":"International Society for Bipolar Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Older adults with bipolar disorder (\n BD<\/jats:styled-content>\n ) are at high risk for severe mood symptoms, cognitive difficulties, and early mortality; however, underlying brain alterations have received little study. Gray matter decreases in ventral prefrontal cortex (\n VPFC<\/jats:styled-content>\n ) seen in younger persons with\n BD<\/jats:styled-content>\n , and additionally in dorsal\n PFC<\/jats:styled-content>\n (\n DPFC<\/jats:styled-content>\n ), are implicated. Here, cortical thickness was examined in an international sample.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cortical thickness in 34 regions was measured from structural magnetic resonance imaging data using enhancing\n neuroImaging<\/jats:styled-content>\n genetics through meta\u2010analysis pipelines for individuals with\n BD<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u2009308) and non\u2010psychiatric comparison participants (\n n<\/jats:italic>\n \u2009=\u2009287), ages 40\u201370y, from six Global Aging and Geriatric Experiments in\n BD<\/jats:styled-content>\n (\n GAGE<\/jats:styled-content>\n \u2010\n BD<\/jats:styled-content>\n ) consortium sites. Group differences were assessed for\n VPFC<\/jats:styled-content>\n ,\n DPFC<\/jats:styled-content>\n and remaining cortical regions, covarying for scanner, age and sex. Results were considered significant corrected for false discovery fate (\n FDR<\/jats:styled-content>\n ) at\n \n p\n FDR<\/jats:sub>\n <\n <\/jats:styled-content>\n \u20090.05. Relationships with demographic and clinical factors were explored.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cortical thickness was significantly lower among\n BD<\/jats:styled-content>\n in\n VPFC<\/jats:styled-content>\n and\n DPFC<\/jats:styled-content>\n , and additional distributed regions (\n \n p\n FDR<\/jats:sub>\n <\n <\/jats:styled-content>\n \u20090.05) and negatively associated with age (\n p<\/jats:italic>\n \u2009<\u20090.05); group and age did not interact significantly. Relationships with\n BD<\/jats:styled-content>\n subtype and medications were observed; lithium was associated with higher frontal pole and anterior cingulate thickness (\n \n p\n FDR<\/jats:sub>\n <\n <\/jats:styled-content>\n \u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this international middle and older aged adult\n BD<\/jats:styled-content>\n sample, lower\n VPFC<\/jats:styled-content>\n cortical thickness was observed, suggesting these deficits persist from younger age.\n DPFC<\/jats:styled-content>\n and additional regions of reduced cortical thickness could contribute to the older adult\n BD<\/jats:styled-content>\n phenotype. Cortical thinning was more pronounced among older individuals regardless of diagnosis. Lithium may lessen cortical thinning.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bdi.70166","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:18:32Z","timestamp":1786169912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-558X","authenticated-orcid":false,"given":"Rebecca","family":"Marks","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven USA"},{"name":"Western Psychiatric Hospital University of Pittsburgh Medical Center Pittsburgh USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven 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