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A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and\/or suicidal behavior history.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We explored relationships among a PRS previously associated with suicidal behavior, VPFC morphology, and suicidal behavior in 376 individuals of European ancestry (mean age 30y; 57% female): 225 with BD (76 suicide attempters (SAs), 149 non\u2010suicide attempters (NSAs)) and 151 healthy control individuals (HCs). We calculated PRS and performed magnetic resonance imaging to assess VPFC (inferior frontal gyrus (IFG) and orbitofrontal cortex) cortical thickness and surface area. Associations were examined among PRS, diagnosis, suicide attempt history, and brain measures.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among individuals with BD, those with higher PRS showed decreased right VPFC surface area, primarily due to IFG reductions (\n p<\/jats:italic>\n \u2009<\u20090.01). A significant group (SA, NSA, HC)\u2013by\u2010PRS interaction was observed for right IFG cortical surface area (\n p<\/jats:italic>\n \u2009<\u20090.05); NSAs with high vs. low PRS had significantly smaller right IFG surface area. The mean PRS was highest for SAs, then NSAs, and lowest for HCs; however, differences did not reach significance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings suggest this suicide PRS may reflect genetic mechanisms influencing IFG differences in BD. Given the modest sample size, replication of these preliminary findings in large\u2010scale diverse cohorts is required to determine whether including this PRS and\/or the corresponding IFG values could improve multimodal BD suicidal behavior prediction algorithms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bdi.70172","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:26:03Z","timestamp":1788945963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-3244","authenticated-orcid":false,"given":"Noa","family":"Katz Shroitman","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Levey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Quatrano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"},{"name":"Neurobiology Research Unit Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Colic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany"},{"name":"German Center of Mental Health Partner Site Halle\u2010Jena\u2010Magdeburg Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-1859","authenticated-orcid":false,"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia L.","family":"Willour","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-4698","authenticated-orcid":false,"given":"Hilary P.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"35","volume-title":"Manic\u2010Depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin F. 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