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However, the state\u2010specific abnormalities in the segmental structural and functional properties of adolescent fiber tracts remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Processed fMRI and DTI data from 19 manic\u2010phase PBD (MPBD), 20 euthymic\u2010phase PBD (EPBD), and 17 matched healthy controls (HCs) were analyzed for structural and functional alterations across 100 segments of 8 WM tracts using Automated Fiber Quantification, with six machine learning classifiers subsequently employed for disease classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tract\u2010based analysis revealed predominant microstructural alterations in the left corticospinal tract (CST), characterized by concurrent increases in FA and CL alongside decreased RD, particularly in the posterior internal capsule and mid\u2010portion of the tract. Functional ALFF abnormalities correlated with manic symptoms and episode frequency, suggesting affective dysregulation in emotion\u2010regulation pathways (including anterior thalamic radiation and inferior fronto\u2010occipital fasciculus). The random forest classifier, trained on a multimodal feature set combining DTI\u2010derived tensor metrics, functional ALFF values, and clinical information, achieved 84% accuracy in distinguishing MPBD patients from HCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multimodal study reveals segmental abnormalities in the structure and function of WM tracts across different mood episodes in PBD, identifying a structure\u2013function desynchronization pattern: motor pathway exhibits enhanced structural integrity with preserved function, whereas emotion\u2010regulation pathways display functional hyperactivity without structural alterations. These alterations correlate with cognitive\u2010executive impairment and enable clinical subtype differentiation, providing novel insights into PBD neuropathology and supporting neuroimaging\u2010based diagnostic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70175","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:28:18Z","timestamp":1787826498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["State\u2010Specific Segmental Abnormalities of White Matter Structure and Function in Pediatric Bipolar Disorders"],"prefix":"10.1111","volume":"28","author":[{"given":"Ziqi","family":"Chen","sequence":"first","affiliation":[{"name":"School of Radiology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Tai'an 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