{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:57:40Z","timestamp":1790848660059,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Categorical classifications of depression, such as DSM\u20105 and ICD, are limited by high clinical heterogeneity, arbitrary diagnostic thresholds, and weak links to underlying pathophysiology. In line with the Research Domain Criteria (RDoC) framework, this article proposes a dimensional and mechanistic approach centered on emotional responses as core transdiagnostic features of mood disorders. Emotional responses are conceptualized along two fundamental dimensions: intensity (arousal) and hedonic valence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This perspective integrates evidence from clinical, psychophysiological, neuroimaging, and preclinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Depressive episodes may be characterized by either emotional hyporeactivity (emotional blunting and reduced responsiveness) or emotional hyperreactivity (heightened distress, anxiety, irritability, and emotional lability), the latter being closely associated with mixed features, particularly in bipolar depression. In parallel, depression is marked by maladaptive valence attribution, encompassing anhedonia related to reward\u2010system dysfunction and a pervasive negativity bias. Preclinical findings implicate dysregulated basolateral amygdala circuits in valence attribution and demonstrate the reversibility of negativity bias with antidepressant interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Integrating emotional intensity and valence within an RDoC\u2010informed framework provides a biologically grounded account of depressive heterogeneity, refines the characterization of mixed states, and offers clinically relevant guidance for treatment selection. This perspective supports the development of personalized therapeutic strategies and the systematic inclusion of emotional dimensions in clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.70182","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:14:59Z","timestamp":1790846099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emotional Responses (Intensity\/Valence) Fulfill RDoC Criteria but Remain Excluded From Diagnostic Classifications of Mood Disorders"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-9604","authenticated-orcid":false,"given":"Chantal","family":"Henry","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Service Hospitalo\u2010Universitaire GHU Paris Psychiatrie &amp; Neurosciences, Sainte\u2010Anne Hospital  Paris France"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 3571, Institut Pasteur Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-8056","authenticated-orcid":false,"given":"Chl\u00f6\u00e9","family":"M\u00fch","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 3571, Institut Pasteur Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"UNIACT, PsyBrain Team, NeuroSpin  Gif\u2010sur\u2010Yvette France"},{"name":"\u00c9cole Doctorale 158 \u2013 Cerveau, Cognition, Comportement Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire\u2010H\u00e9l\u00e8ne","family":"de Badts","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 3571, Institut Pasteur Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Alonso","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 3571, Institut Pasteur Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-7921","authenticated-orcid":false,"given":"Lucie","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Service Hospitalo\u2010Universitaire GHU Paris Psychiatrie &amp; Neurosciences, Sainte\u2010Anne Hospital  Paris France"},{"name":"Institut de Neuromodulation GHU Paris Psychiatrie and Neurosciences, Sainte\u2010Anne Hospital, University Paris Cit\u00e9  Paris France"},{"name":"Cognitive Neuroimaging Unit, NeuroSpin, INSERM\u2010CEA University Paris\u2010Saclay  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u2010126"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12518"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100325\u20104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.09.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723002544"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15121509"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358808"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.20230015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/wps.21300","article-title":"Bipolar II Disorder: A State\u2010Of\u2010The\u2010Art Review","volume":"24","author":"Berk M.","year":"2025","journal-title":"World Psychiatry"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020185"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.155"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16030353"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0539018405058216"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0077714"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579405050340"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2020.11.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.10.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010010\u20100156\u20100"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jad.2006.10.027","article-title":"Towards a Reconceptualization of Mixed States Based on an Emotional Reactivity Dimensional Model","volume":"101","author":"Henry C.","year":"2007","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u20108\u201082"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2741\/e578"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098493"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.11.016"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","DOI":"10.1097\/00005053-192104000-00057","volume-title":"Manic\u2010Depressive Insanity and Paranoia","author":"Kraepelin E.","year":"1921"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0963\u20107214.2005.00354.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867417691850"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12976"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493690"},{"issue":"4","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0006-3223(99)00025-6","article-title":"Affective Startle Modulation in Clinical Depression: Preliminary Findings","volume":"46","author":"Allen N. B.","year":"1999","journal-title":"Biological Psychiatry"},{"issue":"5","key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archpsyc.1983.01790050083010","article-title":"Electrodermal Activity in Euthymic Unipolar and Bipolar Affective Disorders: Evidence for a Trait Marker","volume":"40","author":"Iacono W. G.","year":"1983","journal-title":"Archives of General Psychiatry"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.04.007"},{"issue":"11","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.biopsych.2009.12.012","article-title":"Impact of Depression and Antidepressant Treatment on Heart Rate Variability: A Review and Meta\u2010Analysis","volume":"67","author":"Kemp A. H.","year":"2010","journal-title":"Biological Psychiatry"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001351"},{"issue":"1","key":"e_1_2_11_38_1","first-page":"7","article-title":"Event\u2010Related Potentials (ERPs) in Depression: Evidence for an Electrophysiological Endophenotype","volume":"31","author":"Kayser J.","year":"2000","journal-title":"Clinical EEG and Neuroscience"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003659"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000118"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S393264"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12927"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.11.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-clinpsy-050212-185606","article-title":"Depression, Stress, and Anhedonia","volume":"10","author":"Pizzagalli D. A.","year":"2014","journal-title":"Annual Review of Clinical Psychology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.06.006"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000122"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010019\u20100644\u2010x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0028813"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2022.07.011"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000244"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415\u2010020\u201000804\u20106"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11123138"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.039"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz167"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131305"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.06.008"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsz096"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045\u20105380\u20101\u201010"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722002720"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2021.01.003"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000367"},{"issue":"3","key":"e_1_2_11_62_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/0963721410370292","article-title":"The Role of the Behavioral Approach System (BAS) in Bipolar Spectrum Disorders","volume":"19","author":"Alloy L. B.","year":"2010","journal-title":"Current Directions in Psychological Science"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121379"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.06.009"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.097"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131752"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004964\u2010y"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14366"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100299\u20109"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003075\u20100"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp7520"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000927\u20100"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033843\u20103"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007679\u20109"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201003085\u20106"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201010965\u20108"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.023"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571300062X"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.149"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852917000165"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12213"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12911"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.09.006"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4602"},{"key":"e_1_2_11_85_1","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.4088\/JCP.14m09092","article-title":"Mixed Features in Patients With a Major Depressive Episode: The BRIDGE\u2010II\u2010MIX Study","volume":"76","author":"Perugi G.","year":"2015","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_11_86_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5234\/cnpt.10.10","article-title":"Early Recognition and Appropriate Pharmacotherapy for Mixed Depression: The Key to Resolving Complex or Treatment\u2010Refractory Clinical Cases","volume":"10","author":"Takeshima M.","year":"2019","journal-title":"Clinical Neuropsychopharmacology and Therapeutics"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/07067437241245384"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116636545"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13135"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.70049"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15060770"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05122032"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12140"},{"issue":"10","key":"e_1_2_11_94_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1176\/appi.ajp.2009.09020149","article-title":"Effect of Acute Antidepressant Administration on Negative Affective Bias in Depressed Patients","volume":"166","author":"Harmer C. J.","year":"2009","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0213"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051\u20105545.2009.tb00245.x"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.36148\/2284\u20100249\u2010376"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1184978"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000559"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103956(01)00038\u20103"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.03.047"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12113"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.3791\/68391"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.70182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bdi.70182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.70182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:15:02Z","timestamp":1790846102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.70182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":103,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/bdi.70182"],"URL":"https:\/\/doi.org\/10.1111\/bdi.70182","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70182"}}