{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:47:52Z","timestamp":1791895672567,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n In clinics, major depressive episodes (MDE) in adolescents and early adults with mood disorders are a prevalent manifestation with limited treatment efficacy. Previous studies have suggested that early\u2010stage treatment response is an important predictor of patients' final clinical outcome. Finding clinical features related to early\u2010stage treatment response is crucial for optimizing interventions and understanding outcome determinants.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a study involving 218 inpatients aged 13\u201325\u2009years with mood disorders currently in MDE. We evaluated patients' multi\u2010dimensional clinical features both at baseline and after 2\u2009weeks of treatment; the main outcome measure was the reduction rate of total the 17\u2010item Hamilton Depression Rating Scale (HAMD\u201017) scores between baseline and 2\u2009weeks of treatment. Logistic regression analysis was applied to identify baseline predictive clinical factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline HAMD total score (OR\u2009=\u20091.10, 95% CI [1.00, 1.20],\n p<\/jats:italic>\n \u2009=\u20090.045) and thought disorder factor scores of Brief Psychiatric Rating Scale (BPRS) (OR\u2009=\u20090.79, 95% CI [0.70, 0.91],\n p<\/jats:italic>\n \u2009<\u20090.001) were significantly associated with early\u2010stage treatment response.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our study contributes to predicting early\u2010stage treatment response in adolescents and young adults with MDE based on baseline clinical features. Baseline HAMD total score and thought disorder factor scores of BPRS are potential clinical predictors. Understanding such factors enhances treatment decision\u2010making and efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bdi.70191","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:58:48Z","timestamp":1791892728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Symptomatology as Predictors of Early Treatment Response in Adolescents and Young Adults With Major Depressive Episode"],"prefix":"10.1111","volume":"28","author":[{"given":"Lifei","family":"Wang","sequence":"first","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tang","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Psychology Xinxiang Medical University Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Lu","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Gao","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Mental Health, School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-2303","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Early Intervention Unit, Department of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China"},{"name":"Functional Brain Imaging Institute of Nanjing Medical University Nanjing China"},{"name":"Department of Mental Health, School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eurpsy.2017.12.009","article-title":"The Incidence, Psychiatric Co\u2010Morbidity and Pharmacological Treatment of Severe Mental Disorders in Children and Adolescents","volume":"49","author":"Nesv\u00e5g R.","year":"2018","journal-title":"European Psychiatry: The Journal of the Association of European Psychiatrists"},{"issue":"7","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S2215-0366(20)30137-1","article-title":"Comparative Efficacy and Acceptability of Antidepressants, Psychotherapies, and Their Combination for Acute Treatment of Children and Adolescents With Depressive Disorder: A Systematic Review and Network Meta\u2010Analysis","volume":"7","author":"Zhou X.","year":"2020","journal-title":"Lancet. 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